Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Desmoplasia

  • Sasser A. Kate
  • Brett M. Hall
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1580-2

Synonyms

Definition

Desmoplasia is the formation of fibrous connective tissue by proliferation of fibroblasts. Desmoplasia is a key component of solid tumor stroma (Fig. 1).

Keywords

Hepatocyte Growth Factor Focal Adhesion Kinase Fibrous Connective Tissue Fibroblast Activation Protein Extracellular Matrix Remodel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bhowmick NA, Neilson EG, Moses HL (2004) Stromal fibroblasts in cancer initiation and progression. Nature 432:332–337CrossRefPubMedPubMedCentralGoogle Scholar
  2. Kunz-Schughart LA, Knuechel R (2002) Tumor-associated fibroblasts (part I): active stromal participants in tumor development and progression? Histol Histopathol 17(2):599–621PubMedGoogle Scholar
  3. Mahadevan D, Von Hoff DD (2007) Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther 6(4):1186–1197CrossRefPubMedGoogle Scholar
  4. Walker RA (2001) The complexities of breast cancer desmoplasia. Breast Cancer Res 3:143–145CrossRefPubMedPubMedCentralGoogle Scholar
  5. Zipori D (2006) The mesenchyme in cancer therapy as a target tumor component, effector cell modality and cytokine expression vehicle. Cancer Metastasis Rev 25:459–467CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Allogeneic. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 138. doi:10.1007/978-3-642-16483-5_194Google Scholar
  2. (2012) Bone Marrow-Derived Mesenchymal Stem Cells. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 446. doi:10.1007/978-3-642-16483-5_681Google Scholar
  3. (2012) Collagen. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 895. doi:10.1007/978-3-642-16483-5_1260Google Scholar
  4. (2012) Extracellular Matrix. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1362. doi:10.1007/978-3-642-16483-5_2067Google Scholar
  5. (2012) Fibroblasts. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1398. doi:10.1007/978-3-642-16483-5_2176Google Scholar
  6. (2012) Genetic Instability. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 1527–1528. doi:10.1007/978-3-642-16483-5_2380Google Scholar
  7. (2012) HGF In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1693. doi:10.1007/978-3-642-16483-5_2710Google Scholar
  8. (2012) Integrin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1884. doi:10.1007/978-3-642-16483-5_3084Google Scholar
  9. (2012) Microenvironment. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2296. doi:10.1007/978-3-642-16483-5_3720Google Scholar
  10. (2012) Myofibroblasts. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 2440–2441. doi:10.1007/978-3-642-16483-5_3944Google Scholar
  11. (2012) Paracrine. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2783. doi:10.1007/978-3-642-16483-5_4380Google Scholar
  12. (2012) Xenograft. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3967. doi:10.1007/978-3-642-16483-5_6278Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of PediatricsColumbus Children’s Research Institute, The Ohio State UniversityColumbusUSA