Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Desmoglein-2

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1577-2

Synonyms

Definition

Dsg2 is one of the calcium-binding transmembrane glycoprotein components of the cell-cell adhesion molecules of the desmosomes. Dsg2 is one of the cadherin cell adhesion molecule superfamily in vertebrate epithelial cells.

Characteristics

Cell Junctions

Epithelial cell-cell junctions consist of four junctions: tight junctions, adherens junctions, desmosomes, and gap junctions (Fig. 1). Two adhering-type junctions, the adherens junctions and the desmosomes, are responsible for strong cell-cell adhesion. Each of these junctions consists of a transmembrane cadherin and a complex cytoplasmic plaque that serve to link cadherin to actin microfilaments or the intermediate filament cytoskeleton.
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References

  1. Buxton RS, Cowin P, Franke WW et al (1993) Nomenclature of the desmosomal cadherins. J Cell Biol 121:481–483CrossRefPubMedGoogle Scholar
  2. Holen I, Whitworth J, Nutter F, et al (2012) Loss of plakoglobin promotes decreased cell-cell contact, increased invasion, and breast cancer cell dissemination in vivo. Breast Cancer Res 14:R86CrossRefPubMedPubMedCentralGoogle Scholar
  3. Jou TS, Stewart DB, Stappert J et al (1995) Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex. Proc Natl Acad Sci U S A 92:5067–5071CrossRefPubMedPubMedCentralGoogle Scholar
  4. Pantel K, Passlick B, Vogt J, et al (1998) Reduced expression of plakoglobin indicates an unfavorable prognosis in subsets of patients with non-small-cell lung cancer. J Clin Oncol 16:1407–1413PubMedGoogle Scholar
  5. Rieger-Christ KM, Ng L, Hanley RS, et al (2005) Restoration of plakoglobin expression in bladder carcinoma cell lines suppresses cell migration and tumorigenic potential. Br J Cancer 92:2153–2159CrossRefPubMedPubMedCentralGoogle Scholar
  6. Tselepis C, Chidgey M, North A et al (1998) Desmosomal adhesion inhibits invasive behavior. Proc Natl Acad Sci U S A 95:8064–8069CrossRefPubMedPubMedCentralGoogle Scholar
  7. Wahl JK, Nieset JE, Sacco-Bubulya PA et al (2000) The amino- and carboxyl-terminal tails of (beta)-catenin reduce its affinity for desmoglein 2. J Cell Sci 113(Pt 10):1737–1745Google Scholar
  8. Yashiro M, Nishioka N, Hirakawa K (2006) Decreased expression of the adhesion molecule desmoglein-2 is associated with diffuse-type gastric carcinoma. Eur J Cancer 42:2397–2403CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Surgical OncologyOsaka City University Graduate School of MedicineOsakaJapan