Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Masakazu YashiroEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1577-2



Dsg2 is one of the calcium-binding transmembrane glycoprotein components of the cell-cell adhesion molecules of the desmosomes. Dsg2 is one of the cadherin cell adhesion molecule superfamily in vertebrate epithelial cells.


Cell Junctions

Epithelial cell-cell junctions consist of four junctions: tight junctions, adherens junctions, desmosomes, and gap junctions (Fig. 1). Two adhering-type junctions, the adherens junctions and the desmosomes, are responsible for strong cell-cell adhesion. Each of these junctions consists of a transmembrane cadherin and a complex cytoplasmic plaque that serve to link cadherin to actin microfilaments or the intermediate filament cytoskeleton.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Surgical OncologyOsaka City University Graduate School of MedicineOsakaJapan