Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Dendritic Cells

  • Nathalie Cools
  • Viggo Van Tendeloo
  • Zwi Berneman
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1556-2

Definition

Dendritic cells are a special subset of leukocytes that form a complex network of antigen-presenting cells (APC) throughout the body. They play a principal role in the initiation of immune responses to invading microorganisms (bacteria, fungi, and viruses), malignant cells, and allografts by activating naïve lymphocytes, by interaction with innate cells, and by the secretion of cytokines. At certain developmental stages they grow branched projections, the dendrites, hence the cell’s name.

Characteristics

Origin and Function

Dendritic cells (DC) were characterized for the first time by Steinman in 1973 based on their distinct morphology with different cytoplasmic extensions, such as dendrites, pseudopodia, and lamellipodia, which give the cell its star-shaped feature. Due to their pronounced morphology, DC have a large surface, ensuring close contact with neighboring cells.

Variations among the tissue distribution of DC and differences in their phenotype and function indicate...

Keywords

Major Histocompatibility Complex Class Tumor Antigen Minimal Residual Disease Costimulatory Molecule Immature Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245–252CrossRefPubMedGoogle Scholar
  2. Gilboa E (2007) DC-based cancer vaccines. J Clin Invest 117:1195–1203CrossRefPubMedPubMedCentralGoogle Scholar
  3. Lotze MT, Thomson AW (2001) Dendritic cells, 2nd edn. Academic, LondonGoogle Scholar
  4. Ponsaerts P, Van Tendeloo VF, Berneman ZN (2003) Cancer immunotherapy using RNA-loaded dendritic cells. Clin Exp Immunol 134:378–384CrossRefPubMedPubMedCentralGoogle Scholar
  5. Van Tendeloo VF, Van Broeckhoven C, Berneman ZW (2001) Gene-based cancer vaccines: an ex vivo approach. Leukemia 15:545–558CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Adhesion molecules. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 66. doi:10.1007/978-3-642-16483-5_96Google Scholar
  2. (2012) Antigen-presenting cells. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 209–210. doi:10.1007/978-3-642-16483-5_321Google Scholar
  3. (2012) Cadherins. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p pp 581–582. doi:10.1007/978-3-642-16483-5_770Google Scholar
  4. (2012) Delayed type hypersensitivity reaction. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1073. doi:10.1007/978-3-642-16483-5_1550Google Scholar
  5. (2012) ELISPOT. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1217. doi:10.1007/978-3-642-16483-5_1850Google Scholar
  6. (2012) Lamellipodia. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1971. doi:10.1007/978-3-642-16483-5_3267Google Scholar
  7. (2012) Langerhans cell. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1975. doi:10.1007/978-3-642-16483-5_3272Google Scholar
  8. (2012) Leukocytes. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2028. doi:10.1007/978-3-642-16483-5_3330Google Scholar
  9. (2012) Major histocompatibility complex. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2137. doi:10.1007/978-3-642-16483-5_3500Google Scholar
  10. (2012) Treg. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3782. doi:10.1007/978-3-642-16483-5_5967Google Scholar
  11. (2012) Tumor-associated antigen. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 3807–3808. doi:10.1007/978-3-642-16483-5_6017Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Nathalie Cools
    • 1
  • Viggo Van Tendeloo
    • 1
  • Zwi Berneman
    • 1
  1. 1.Vaccine and Infections Disease Institute (VAXINFECTIO) Laboratory of Experimental HematologyFaculty of Medicine and Health Sciences, University of AntwerpEdegemBelgium