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Deleted in Pancreatic Carcinoma Locus 4

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Encyclopedia of Cancer

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Synonyms

MADH4; Mother against decapentaplegic, drosophila, homolog of 4; SMA- and MAD-related protein 4; SMAD4; DPC4

Definition

Deleted in pancreatic carcinoma locus 4 (DPC4) belongs to the class of tumor suppressor genes (tumor suppressor genes). It was identified within chromosomal band 18q21.1, which is frequently deleted in pancreatic carcinoma. DPC4 is a component of the transcription complex (transcriptional complex) that mediates cell surface signals to the nucleus which are initiated by transforming growth factor β [TGF-β]-related growth and differentiation factors.

Characteristics

The open reading frame of DPC4 spans 1,656 nucleotides and comprises 11 exons that code for a 60 kD protein (552 amino acids). DPC4 belongs to the highly conserved family of Smad genes that has been identified by protein sequence homology studies. The founding member Mad (Mother against decapentaplegic) was identified in Drosophila melanogaster.

Mad and its homologs mediate signals from cell surface...

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References

  • Alberici P, Jagmohan-Changur S, De Pater E et al (2005) Smad4 haploinsufficiency in mouse models for intestinal cancer. Oncogene 25:1841–1851

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  • Howe JR, Roth S, Ringold JC et al (1998) Mutations in the smad/dpc4 gene in juvenile polyposis. Science 280:1086–1088

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Author information

Authors and Affiliations

  1. University of Bochum, Bochum, Germany

    Stephan A. Hahn

Authors
  1. Stephan A. Hahn
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Corresponding author

Correspondence to Stephan A. Hahn .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Hahn, S.A. (2015). Deleted in Pancreatic Carcinoma Locus 4. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1552-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1552-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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