Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Deleted in Pancreatic Carcinoma Locus 4

  • Stephan A. Hahn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1552-2

Synonyms

Definition

Deleted in pancreatic carcinoma locus 4 (DPC4) belongs to the class of tumor suppressor genes (tumor suppressor genes). It was identified within chromosomal band 18q21.1, which is frequently deleted in pancreatic carcinoma. DPC4 is a component of the transcription complex (transcriptional complex) that mediates cell surface signals to the nucleus which are initiated by transforming growth factor β [TGF-β]-related growth and differentiation factors.

Characteristics

The open reading frame of DPC4 spans 1,656 nucleotides and comprises 11 exons that code for a 60 kD protein (552 amino acids). DPC4 belongs to the highly conserved family of Smad genes that has been identified by protein sequence homology studies. The founding member Mad (Mother against decapentaplegic) was identified in Drosophila melanogaster.

Mad and its homologs mediate signals from cell surface...

Keywords

Pancreatic Carcinoma Bone Morphogenic Protein Smad Gene Smad Complex Bone Morphogenic Protein Signaling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Alberici P, Jagmohan-Changur S, De Pater E et al (2005) Smad4 haploinsufficiency in mouse models for intestinal cancer. Oncogene 25:1841–1851CrossRefGoogle Scholar
  2. Hahn SA, Schutte M, Hoque AT et al (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271:350–353CrossRefPubMedGoogle Scholar
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  5. Takaku K, Oshima M, Miyoshi H et al (1998) Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92:645–656CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.University of BochumBochumGermany