Deleted in Malignant Brain Tumors 1
DMBT1 located at chromosome 10q26.13 2 was initially identified as a gene that shows frequent homozygous deletions in malignant brain tumors. It codes for an extracellular glycoprotein of the evolutionary highly conserved group of scavenger receptor cysteine-rich (SRCR) proteins, and it is widely expressed in human tissues with strongest expression in epithelia and associated glands. Based on genomic alterations and loss of expression in several cancer types, DMBT1 has been proposed to play a role in tumorigenesis. The currently available data suggests two physiological functions for DMBT1: a function in innate immunity/mucosal protection and a function in epithelial/stem cell differentiation and regenerative processes.
The human DMBT1-locus is built up...