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Decoy Receptor 3

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

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Synonyms

DcR3

Definition

DcR3 is a member of the TNF receptor superfamily (TNFRSF6B), and the DcR3 gene is mapped to chromosome 20q13.3. DcR3 is a glycosylated protein of 300 amino acids and 33 kD. The receptor lacks a transmembrane domain and exists as soluble protein.

Characteristics

Tissue Expression and Decoy Function of DcR3

DcR3 is generally undetectable in normal tissues but is highly expressed in several human malignant tissues, such as adenocarcinomas of the esophagus, stomach, colon, rectum, pancreas and lung, glioblastomas, and lymphomas. In addition, high serum levels of DcR3 have been detected in many cancer patients. Clinical data indicate the significance of detecting serum DcR3 as a novel parameter for the diagnosis, treatment, and prognosis of malignancies. Several lines of evidence suggest a significant role for DcR3 in immune suppression and tumor progression. DcR3 has been regarded to function as decoy receptor for FasL, LIGHT (homologous to lymphotoxins, shows indu...

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References

  • Chang YC, Chan YH, Jackson DG et al (2006) The glycosaminoglycan binding domain of decoy receptor 3 is essential for induction of monocyte adhesion. J Immunol 176:173–180

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  • Chang YC, Hsu TL, Lin HH et al (2004) Modulation of macrophage differentiation and activation by decoy receptor 3. J Leukoc Biol 75:486–494

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  • Hsu TL, Chang YC, Chen SJ et al (2002) Modulation of dendritic cell differentiation and maturation by decoy receptor 3. J Immunol 168:4846–4853

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  • Yang CR, Hsieh SL, Teng CM et al (2004) Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, a cytokine belonging to TNF superfamily and exhibiting angiostatic action. Cancer Res 64:1122–1129

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  • Yang CR, Hsieh SL, Ho FM et al (2005) Decoy receptor 3 increases monocyte adhesion to endothelial cells via NF-κB-dependent up-regulation of intercellular adhesion molecule-1, VCAM-1, and IL-8 expression. J Immunol 174:1647–1656

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See Also

  • (2012) HVEM. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, pp 1766-1767. doi: 10.1007/978-3-642-16483-5_2872

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, National Yang-Ming University, Immunology Research Center, Taipei Veterans General Hospital; Genomics Research Center, Academia Sinica, Taipei, Taiwan

    Shie-Liang Hsieh

  2. Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan

    Wan-Wan Lin

Authors
  1. Shie-Liang Hsieh
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  2. Wan-Wan Lin
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Corresponding author

Correspondence to Shie-Liang Hsieh .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Hsieh, SL., Lin, WW. (2015). Decoy Receptor 3. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1545-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1545-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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