Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Decoy Receptor 3

  • Shie-Liang Hsieh
  • Wan-Wan Lin
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1545-2

Synonyms

Definition

DcR3 is a member of the TNF receptor superfamily (TNFRSF6B), and the DcR3 gene is mapped to chromosome 20q13.3. DcR3 is a glycosylated protein of 300 amino acids and 33 kD. The receptor lacks a transmembrane domain and exists as soluble protein.

Characteristics

Tissue Expression and Decoy Function of DcR3

DcR3 is generally undetectable in normal tissues but is highly expressed in several human malignant tissues, such as adenocarcinomas of the esophagus, stomach, colon, rectum, pancreas and lung, glioblastomas, and lymphomas. In addition, high serum levels of DcR3 have been detected in many cancer patients. Clinical data indicate the significance of detecting serum DcR3 as a novel parameter for the diagnosis, treatment, and prognosis of malignancies. Several lines of evidence suggest a significant role for DcR3 in immune suppression and tumor progression. DcR3 has been regarded to function as decoy receptor for FasL, LIGHT (homologous to lymphotoxins, shows indu...

Keywords

Osteoclast Formation Decoy Receptor Monocyte Adhesion Induce Tumor Cell Death Host Immune Surveillance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Chang YC, Chan YH, Jackson DG et al (2006) The glycosaminoglycan binding domain of decoy receptor 3 is essential for induction of monocyte adhesion. J Immunol 176:173–180CrossRefPubMedGoogle Scholar
  2. Chang YC, Hsu TL, Lin HH et al (2004) Modulation of macrophage differentiation and activation by decoy receptor 3. J Leukoc Biol 75:486–494CrossRefPubMedGoogle Scholar
  3. Hsu TL, Chang YC, Chen SJ et al (2002) Modulation of dendritic cell differentiation and maturation by decoy receptor 3. J Immunol 168:4846–4853CrossRefPubMedGoogle Scholar
  4. Yang CR, Hsieh SL, Teng CM et al (2004) Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, a cytokine belonging to TNF superfamily and exhibiting angiostatic action. Cancer Res 64:1122–1129CrossRefPubMedGoogle Scholar
  5. Yang CR, Hsieh SL, Ho FM et al (2005) Decoy receptor 3 increases monocyte adhesion to endothelial cells via NF-κB-dependent up-regulation of intercellular adhesion molecule-1, VCAM-1, and IL-8 expression. J Immunol 174:1647–1656CrossRefPubMedGoogle Scholar

See Also

  1. (2012) HVEM. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, pp 1766-1767. doi: 10.1007/978-3-642-16483-5_2872Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Microbiology and ImmunologyNational Yang-Ming University, Immunology Research Center, Taipei Veterans General Hospital; Genomics Research Center, Academia SinicaTaipeiTaiwan
  2. 2.Department of PharmacologyCollege of Medicine, National Taiwan UniversityTaipeiTaiwan