Decoy Receptor 3
DcR3 is a member of the TNF receptor superfamily (TNFRSF6B), and the DcR3 gene is mapped to chromosome 20q13.3. DcR3 is a glycosylated protein of 300 amino acids and 33 kD. The receptor lacks a transmembrane domain and exists as soluble protein.
Tissue Expression and Decoy Function of DcR3
DcR3 is generally undetectable in normal tissues but is highly expressed in several human malignant tissues, such as adenocarcinomas of the esophagus, stomach, colon, rectum, pancreas and lung, glioblastomas, and lymphomas. In addition, high serum levels of DcR3 have been detected in many cancer patients. Clinical data indicate the significance of detecting serum DcR3 as a novel parameter for the diagnosis, treatment, and prognosis of malignancies. Several lines of evidence suggest a significant role for DcR3 in immune suppression and tumor progression. DcR3 has been regarded to function as decoy receptor for FasL, LIGHT (homologous to lymphotoxins, shows indu...
KeywordsOsteoclast Formation Decoy Receptor Monocyte Adhesion Induce Tumor Cell Death Host Immune Surveillance
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