Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Decatenation G2 Checkpoint

  • William K. Kaufmann
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1541-3

Definition

A surveillance system that ensures that mitosis does not begin when topoisomerase IIα is locked in the closed clamp conformation by topoII catalytic inhibitors.

Characteristics

During DNA replication, daughter DNA duplexes become catenated or entangled through knots and links. These knots and links must be removed before sister chromatids can be properly segregated during mitosis. Type II DNA topoisomerases are enzymes that remove knots and links through a concerted set of reactions in which a protein-associated DNA double-strand break is generated, another segment of DNA is passed through the break, and the protein-associated double-strand break is reversed. The decatenation G2 checkpoint is an active signal transduction pathway that monitors topoisomerase IIα catalytic status and controls the location and/or activity of mitosis-promoting factor to delay the onset of mitosis.

Molecular Biology

Drugs that inhibit topoisomerase II fall into two groups known as poisons and...

Keywords

Cancer Stem Cell Sister Chromatid Chromosomal Instability Human Hematopoietic Stem Cell Catalytic Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bower JJ, Karaca GF, Zhou Y, Simpson DA et al (2010) Topoisomerase IIα maintains genomic stability through decatenation G(2) checkpoint signaling. Oncogene 29:4784–4799CrossRefGoogle Scholar
  2. Damelin M, Sun YE, Sodja VB et al (2005) Decatenation checkpoint deficiency in stem and progenitor cells. Cancer Cell 8:479–484CrossRefPubMedGoogle Scholar
  3. Downes CS, Clarke DJ, Mullinger AM et al (1994) A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells. Nature 372:467–470CrossRefPubMedGoogle Scholar
  4. Lou Z, Minter-Dykhouse K, Chen J (2005) BRCA1 participates in DNA decatenation. Nat Struct Mol Biol 12:589–593CrossRefPubMedGoogle Scholar
  5. Luo K, Yuan J, Chen J, Lou Z (2009) Topoisomerase IIα controls the decatenation checkpoint. Nat Cell Biol 11:204–210CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineUniversity of North Carolina at Chapel HillChapel HillUSA