Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Death Receptors

  • Manfred SchwabEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1539-2

Definition

Death receptors belong to the tumor necrosis factor (TNF) receptor gene superfamily, which is defined by similar, cysteine-rich extracellular domains. The death receptors also contain a homologous cytoplasmic sequence termed the “death domain.” Death domains typically enable death receptors to engage the cell’s apoptotic machinery, but in some instances they mediate functions that are distinct from or even counteract apoptosis. Some molecules that transmit signals from death receptors contain death domains themselves.

Cross-References

See Also

  1. (2012) Death domain. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1065. doi: 10.1007/978-3-642-16483-5_1534Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany