Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

DNA Damage Response Genes

  • Kandace Williams
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1510-6


DNA damage response genes encompass all genes that encode proteins required for either direct or indirect response to DNA damage. The proteins encoded by these genes either act to help repair the damaged DNA within replicating cells or if damage is sufficient, to activate cell cycle checkpoints and if too severe, to activate cell death pathways. Each of the above enzymatic pathways also includes posttranslational modifiers such as protein kinases, phosphorylases, ubiquitin ligases, acetylators, sumoylators, methylators, scaffolding proteins required for proteasome complexes, and epigenetic gene silencing pathways. MicroRNA-mediated transcriptional regulation will likely be included in the future, as more information is gathered about this gene regulation system. The number of individual pathways and genetic sequences contributing to the major pathways above are unknown but likely encompass several 100 or more.


This essay will focus primarily on mutated genes...


Nucleotide Excision Repair Base Excision Repair Fanconi Anemia Xeroderma Pigmentosum Werner Syndrome 
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See Also

  1. (2012) ATR. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 302. doi:10.1007/978-3-642-16483-5_443Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Biochemistry and Cancer Biology, Health Science CampusUT College of MedicineToledoUSA