Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cytotoxic T-Cells

  • Marc Schmitz
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1500-5

Definition

CD8+ cytotoxic T cells (CTLs) are major cellular components of the adaptive immune system. They efficiently recognize and destroy virus-infected host cells or tumor cells, which expose antigenic peptides bound to major histocompatibility complex (MHC) class I molecules.

Characteristics

Dendritic Cells Play a Major Role in the Induction of CD8+ T Cell Responses

CD8+ CTLs can be efficiently activated by “professional” antigen-presenting cells (APCs) such as dendritic cells (DCs), which display the appropriate MHC class I-peptide complexes on their surface. DCs are the most effective APCs for stimulating naïve T cells that have not recognized and responded to antigens. Besides their extraordinary capability to initiate CD8+ T cell responses, DCs also essentially contribute to the maintenance and regulation of previously activated CD8+ CTLs. Macrophages and B lymphocytes also function as APCs, but mostly for previously stimulated T cells rather than for naïve T cells.

DCs...

Keywords

Major Histocompatibility Complex Class Costimulatory Molecule Chimeric Antigen Receptor Antigen Recognition Bone Marrow Progenitor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institut für ImmunologieTechnische Universität DresdenDresdenGermany