CD8+ cytotoxic T cells (CTLs) are major cellular components of the adaptive immune system. They efficiently recognize and destroy virus-infected host cells or tumor cells, which expose antigenic peptides bound to major histocompatibility complex (MHC) class I molecules.
Dendritic Cells Play a Major Role in the Induction of CD8+ T Cell Responses
CD8+ CTLs can be efficiently activated by “professional” antigen-presenting cells (APCs) such as dendritic cells (DCs), which display the appropriate MHC class I-peptide complexes on their surface. DCs are the most effective APCs for stimulating naïve T cells that have not recognized and responded to antigens. Besides their extraordinary capability to initiate CD8+ T cell responses, DCs also essentially contribute to the maintenance and regulation of previously activated CD8+ CTLs. Macrophages and B lymphocytes also function as APCs, but mostly for previously stimulated T cells rather than for naïve T cells.
KeywordsMajor Histocompatibility Complex Class Costimulatory Molecule Chimeric Antigen Receptor Antigen Recognition Bone Marrow Progenitor Cell
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