Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cytoskeleton

  • Francisco Rivero
  • Huajiang Xiong
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1491-9

Definition

The cytoskeleton is a complex network of interconnected filaments and tubules that extends mainly throughout the cytosol, reaching from the nuclear envelope to the inner surface of the plasma membrane. It gives shape to the cell, mediates anchoring to the substrate and to other cells, facilitates cell movements and movement of organelles, and is necessary for cell division. Although mainly cytosolic, some cytoskeleton components play roles within the nucleus.

Typical eukaryotic cells possess three cytoskeleton systems (Fig. 1) that can be distinguished on the basis of their diameter: microfilaments (MFs) (or actin filaments), intermediate filaments (IFs), and microtubules (MTs).

Keywords

Actin Filament Familial Mediterranean Fever Primary Cilium Anaplastic Large Cell Lymphoma Thick Filament 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Campellone KG, Welch MD (2010) A nucleator arms race: cellular control of actin assembly. Nat Rev Mol Cell Biol 11:237–251CrossRefPubMedPubMedCentralGoogle Scholar
  2. Godsel LM, Hobbs RP, Green KJ (2007) Intermediate filament assembly: dynamics to disease. Trends Cell Biol 18:28–37CrossRefGoogle Scholar
  3. Wade RH (2009) On and around microtubules: an overview. Mol Biotechnol 43:177–191CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Centre for Cardiovascular and Metabolic ResearchThe Hull York Medical School, University of HullHullUK
  2. 2.Department of Zoophysiology, Zoological InstituteChristian-Albrechts-University of KielKielGermany