Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cytokine Receptor as the Target for Immunotherapy and Immunotoxin Therapy

  • Koji Kawakami
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1476-2

Synonyms

Definition

Cancer immunotherapy is the treatment of cancer by improving the ability of a tumor-bearing individual to reject the tumor immunologically. In the case of immunotherapy targeting cytokine receptors, delivery of tumor antigen proteins induces immune response against cancer cells bearing such tumor antigen to eliminate them. Cytokine receptor-targeting immunotoxins are proteins containing a bacterial toxin or chemical compound along with an antibody or a ligand that binds specifically to its target receptor. Immunotoxins then internalize through the receptors and achieve cytotoxic effect derived from the toxin moiety.

Characteristics

When cancer cells are generated in a body, a variety of mechanisms cooperate in order to kill the cancer cells. Among these mechanisms, the immune system has an important role to eliminate tumor tissues. First, immunocytes like macrophagesand natural killer (NK) cells are...

Keywords

Acute Myeloid Leukemia Cancer Vaccine Epitope Peptide Protein Toxin Orphan Drug Designation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Kawakami K, Nakajima O, Morishita R et al (2006) Targeted anticancer immunotoxins and cytotoxic agents with direct killing moieties. Scientific World J 6:781–790CrossRefGoogle Scholar
  2. Pastan I, Hassan R, Fitzgerald DJ et al (2006) Immunotoxin therapy of cancer. Nat Rev Cancer 6:559–565CrossRefPubMedGoogle Scholar
  3. Schuster M, Nechansky A, Kircheis R (2006) Cancer immunotherapy. Biotechnol J 1:138–147CrossRefPubMedGoogle Scholar

See Also

  1. (2012) CTL. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1012. doi: 10.1007/978-3-642-16483-5_1406Google Scholar
  2. (2012) Cytokine Receptor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1052. doi: 10.1007/978-3-642-16483-5_1475Google Scholar
  3. (2012) Diphtheria Toxin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1124. doi: 10.1007/978-3-642-16483-5_1636Google Scholar
  4. (2012) Pseudomonas Exotoxin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3112. doi: 10.1007/978-3-642-16483-5_4841Google Scholar
  5. (2012) Renal Cancer. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 3225-3226. doi: 10.1007/978-3-642-16483-5_6575Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Pharmacoepidemiology, Graduate School of Medicine and Public HealthKyoto UniversityKyotoJapan