Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cytochalasin B

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1457-2

Definition

The alkaloid cytochalasin B is a cell-permeable mycotoxin which inhibits cytoplasmic division by blocking the formation of contractile actin filaments. Cytochalasin B shortens actin filaments by blocking monomer addition at the fast-growing end of actin polymers. It blocks cytokinesis thus preventing the separation of daughter cells after mitosis that leads to the formation of binucleated cells.

Cross-References

Keywords

Cancer Research Actin Filament Daughter Cell Actin Polymer Binucleated Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

See Also

  1. (2012) Cytokinesis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1055. doi: 10.1007/978-3-642-16483-5_1477Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany