The alkaloid cytochalasin B is a cell-permeable mycotoxin which inhibits cytoplasmic division by blocking the formation of contractile actin filaments. Cytochalasin B shortens actin filaments by blocking monomer addition at the fast-growing end of actin polymers. It blocks cytokinesis thus preventing the separation of daughter cells after mitosis that leads to the formation of binucleated cells.
KeywordsCancer Research Actin Filament Daughter Cell Actin Polymer Binucleated Cell
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