Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cyclin G-Associated Kinase

  • Mira R. Ray
  • Paul S. Rennie
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1430-2



GAK/auxilin-2 is the ubiquitously expressed form of the neuronal-specific protein Auxilin-1. GAK is a member of the Ark/Prk serine/threonine protein kinases family and has an important role in endocytosis, un-coating clathrin-coated vesicles (CCVs) in nonneuronal cells, and clathrin-dependent trafficking from the trans-Golgi network. GAK has been implicated as a transcriptional coactivator of the androgen receptor (AR) and may have a role in prostate cancer progression to androgen-independent disease. Expression patterns during androgen-withdrawal therapy suggest a prognostic role for GAK in advanced prostate cancer.


GAK is a large, 140 kDa protein that has three functional domains: (i) an NH 2-terminal Ser/Thr kinase domain, (ii) a central Auxilin/Tensin homology domain, and (iii) a COOH-terminal J-domain (Fig. 1). Although GAK was initially identified by its association with cyclin G, which is a downstream transcriptional target and...


Androgen Receptor Advanced Prostate Cancer Prostate Cancer Progression Nonneuronal Cell Androgen Ablation Therapy 
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  1. Greener T, Zhao X, Nojima H et al (2000) Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Cell Sci 275(2):1365–1370Google Scholar
  2. Heinlein CA, Chang C (2002) Androgen receptor (AR) coregulators: an overview. Endocr Rev 23(2):175–200CrossRefPubMedGoogle Scholar
  3. Ray MR, Wafa LA, Cheng H et al (2006) Cyclin G-associated kinase: a novel androgen receptor-interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer. Int J Cancer 118(5):1108–1119CrossRefPubMedGoogle Scholar

See Also

  1. (2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2747. doi:10.1007/978-3-642-16483-5_4331Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.The Prostate Centre at Vancouver General HospitalUniversity of British ColumbiaVancouverCanada