Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cyclin G-Associated Kinase

  • Mira R. Ray
  • Paul S. Rennie
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1430-2

Synonyms

Definition

GAK/auxilin-2 is the ubiquitously expressed form of the neuronal-specific protein Auxilin-1. GAK is a member of the Ark/Prk serine/threonine protein kinases family and has an important role in endocytosis, un-coating clathrin-coated vesicles (CCVs) in nonneuronal cells, and clathrin-dependent trafficking from the trans-Golgi network. GAK has been implicated as a transcriptional coactivator of the androgen receptor (AR) and may have a role in prostate cancer progression to androgen-independent disease. Expression patterns during androgen-withdrawal therapy suggest a prognostic role for GAK in advanced prostate cancer.

Characteristics

GAK is a large, 140 kDa protein that has three functional domains: (i) an NH 2-terminal Ser/Thr kinase domain, (ii) a central Auxilin/Tensin homology domain, and (iii) a COOH-terminal J-domain (Fig. 1). Although GAK was initially identified by its association with cyclin G, which is a downstream transcriptional target and...

Keywords

Androgen Receptor Advanced Prostate Cancer Prostate Cancer Progression Nonneuronal Cell Androgen Ablation Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Greener T, Zhao X, Nojima H et al (2000) Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Cell Sci 275(2):1365–1370Google Scholar
  2. Heinlein CA, Chang C (2002) Androgen receptor (AR) coregulators: an overview. Endocr Rev 23(2):175–200CrossRefPubMedGoogle Scholar
  3. Ray MR, Wafa LA, Cheng H et al (2006) Cyclin G-associated kinase: a novel androgen receptor-interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer. Int J Cancer 118(5):1108–1119CrossRefPubMedGoogle Scholar

See Also

  1. (2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2747. doi:10.1007/978-3-642-16483-5_4331Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.The Prostate Centre at Vancouver General HospitalUniversity of British ColumbiaVancouverCanada