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Cyclin G-Associated Kinase

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Encyclopedia of Cancer

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Synonyms

Auxilin-2; GAK

Definition

GAK/auxilin-2 is the ubiquitously expressed form of the neuronal-specific protein Auxilin-1. GAK is a member of the Ark/Prk serine/threonine protein kinases family and has an important role in endocytosis, un-coating clathrin-coated vesicles (CCVs) in nonneuronal cells, and clathrin-dependent trafficking from the trans-Golgi network. GAK has been implicated as a transcriptional coactivator of the androgen receptor (AR) and may have a role in prostate cancer progression to androgen-independent disease. Expression patterns during androgen-withdrawal therapy suggest a prognostic role for GAK in advanced prostate cancer.

Characteristics

GAK is a large, 140 kDa protein that has three functional domains: (i) an NH2-terminal Ser/Thr kinase domain, (ii) a central Auxilin/Tensin homology domain, and (iii) a COOH-terminal J-domain (Fig. 1). Although GAK was initially identified by its association with cyclin G, which is a downstream transcriptional target and...

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References

  • Greener T, Zhao X, Nojima H et al (2000) Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Cell Sci 275(2):1365–1370

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  • Heinlein CA, Chang C (2002) Androgen receptor (AR) coregulators: an overview. Endocr Rev 23(2):175–200

    Article  CAS  PubMed  Google Scholar 

  • Ray MR, Wafa LA, Cheng H et al (2006) Cyclin G-associated kinase: a novel androgen receptor-interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer. Int J Cancer 118(5):1108–1119

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See Also

  • (2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2747. doi:10.1007/978-3-642-16483-5_4331

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Author information

Authors and Affiliations

  1. The Prostate Centre at Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada

    Mira R. Ray & Paul S. Rennie

Authors
  1. Mira R. Ray
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  2. Paul S. Rennie
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Corresponding author

Correspondence to Mira R. Ray .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Ray, M.R., Rennie, P.S. (2015). Cyclin G-Associated Kinase. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1430-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1430-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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