Living reference work entry
Human Cripto-1 is a cell membrane-associated protein important for embryonic development, stem cell renewal, and tumorigenesis.
Structure of Cripto-1, a Member of the EGF-CFC Protein Family
Human Cripto-1 (CR-1), originally identified from a human embryonal carcinoma cDNA library, is the founding member of the epidermal growth factor (EGF)-CFC (Cripto in humans, FRL1 in Xenopus, and Cryptic in mice) family of proteins identified only in vertebrates. The EGF-CFC protein family includes monkey Cripto-1, mouse Cripto-1 (Cr-1), chicken Cripto-1, zebra fish one-eyed pinhead ( oep), XenopusFRL1, and mouse and human Cryptic. EGF-CFC proteins contain multiple domains consisting of an amino-terminal signal peptide, a modified EGF-like domain, a cystein-rich CFC motif, and a short hydrophobic carboxy-terminus containing, in some cases, consensus sequences for a glycosylphosphatidylinositol (GPI) anchorage site...
KeywordsEmbryonic Stem Cell Mouse Mammary Tumor Virus Whey Acidic Protein Mouse Mammary Epithelial Cell Intraductal Hyperplasia
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