Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cripto-1

  • Caterina Bianco
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1374-2

Synonyms

Definition

Human Cripto-1 is a cell membrane-associated protein important for embryonic development, stem cell renewal, and tumorigenesis.

Characteristics

Structure of Cripto-1, a Member of the EGF-CFC Protein Family

Human Cripto-1 (CR-1), originally identified from a human embryonal carcinoma cDNA library, is the founding member of the epidermal growth factor (EGF)-CFC (Cripto in humans, FRL1 in Xenopus, and Cryptic in mice) family of proteins identified only in vertebrates. The EGF-CFC protein family includes monkey Cripto-1, mouse Cripto-1 (Cr-1), chicken Cripto-1, zebra fish one-eyed pinhead ( oep), XenopusFRL1, and mouse and human Cryptic. EGF-CFC proteins contain multiple domains consisting of an amino-terminal signal peptide, a modified EGF-like domain, a cystein-rich CFC motif, and a short hydrophobic carboxy-terminus containing, in some cases, consensus sequences for a glycosylphosphatidylinositol (GPI) anchorage site...

Keywords

Embryonic Stem Cell Mouse Mammary Tumor Virus Whey Acidic Protein Mouse Mammary Epithelial Cell Intraductal Hyperplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bianco C, Normanno N, Salomon DS et al (2004) Role of the cripto (EGF-CFC) family in embryogenesis and cancer. Growth Factors 22:133–139CrossRefPubMedGoogle Scholar
  2. Bianco C, Strizzi L, Normanno N et al (2005) Cripto-1: an oncofetal gene with many faces. Curr Top Dev Biol 67:85–133CrossRefPubMedGoogle Scholar
  3. Strizzi L, Bianco C, Normanno N et al (2005) Cripto-1: a multifunctional modulator during embryogenesis and oncogenesis. Oncogene 24:5731–5741CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Division of Extramural ActivitiesNational Institutes of HealthRockvilleUSA