Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Caterina Bianco
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1374-2



Human Cripto-1 is a cell membrane-associated protein important for embryonic development, stem cell renewal, and tumorigenesis.


Structure of Cripto-1, a Member of the EGF-CFC Protein Family

Human Cripto-1 (CR-1), originally identified from a human embryonal carcinoma cDNA library, is the founding member of the epidermal growth factor (EGF)-CFC (Cripto in humans, FRL1 in Xenopus, and Cryptic in mice) family of proteins identified only in vertebrates. The EGF-CFC protein family includes monkey Cripto-1, mouse Cripto-1 (Cr-1), chicken Cripto-1, zebra fish one-eyed pinhead ( oep), XenopusFRL1, and mouse and human Cryptic. EGF-CFC proteins contain multiple domains consisting of an amino-terminal signal peptide, a modified EGF-like domain, a cystein-rich CFC motif, and a short hydrophobic carboxy-terminus containing, in some cases, consensus sequences for a glycosylphosphatidylinositol (GPI) anchorage site...


Embryonic Stem Cell Mouse Mammary Tumor Virus Whey Acidic Protein Mouse Mammary Epithelial Cell Intraductal Hyperplasia 
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  1. Bianco C, Normanno N, Salomon DS et al (2004) Role of the cripto (EGF-CFC) family in embryogenesis and cancer. Growth Factors 22:133–139CrossRefPubMedGoogle Scholar
  2. Bianco C, Strizzi L, Normanno N et al (2005) Cripto-1: an oncofetal gene with many faces. Curr Top Dev Biol 67:85–133CrossRefPubMedGoogle Scholar
  3. Strizzi L, Bianco C, Normanno N et al (2005) Cripto-1: a multifunctional modulator during embryogenesis and oncogenesis. Oncogene 24:5731–5741CrossRefPubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Division of Extramural ActivitiesNational Institutes of HealthRockvilleUSA