Definition
Convection-enhanced delivery (CED) is a novel delivery method that allows direct drug infusion into the brain in a locoregional manner. The delivery is accomplished through surgically implanted catheters in the brain that are connected to external drug infusion pumps that generate a positive infusion pressure. This positive pressure begins the process of convection, which is the augmentation and maintenance of the brain’s normal physiologic bulk flow of interstitial fluid. The enhanced bulk flow through the interstitial space acts as the carrier of the desired agent.
Characteristics
High-grade primary brain tumors, such as glioblastoma multiforme, remain one of the most challenging diagnoses to treat effectively. Despite a range of therapeutic options and their combinations, including surgical resection, external beam radiation therapy, and chemotherapy, the...
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References
Krauze MT, Forsayeth J, Park JW et al (2006) Real-time imaging and quantification of brain delivery of liposomes. Pharm Res 23:2493–2504
Muro K, Das S, Raizer JJ (2006) Convection-enhanced and local delivery of targeted cytotoxins in the treatment of malignant gliomas. Technol Cancer Res Treat 5:201–213
Vogelbaum MA (2007) Convection enhanced delivery for treating brain tumors and selected neurological disorders: symposium review. J Neurooncol 87:97–109
See Also
(2012) Cerebral Edema. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 750. doi: 10.1007/978-3-642-16483-5_1034
(2012) Diffusion. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1116. doi: 10.1007/978-3-642-16483-5_1620
(2012) Ependyma. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1267. doi: 10.1007/978-3-642-16483-5_1926
(2012) Gyrus. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1620. doi: 10.1007/978-3-642-16483-5_2542
(2012) Interstitial Space. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1899. doi: 10.1007/978-3-642-16483-5_3110
(2012) Liposomes. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2063. doi: 10.1007/978-3-642-16483-5_3388
(2012) Monoclonal Antibody. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2367. doi: 10.1007/978-3-642-16483-5_6842
(2012) Pharmacokinetics. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2845. doi: 10.1007/978-3-642-16483-5_4500
(2012) Subarachnoid Space. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3552. doi: 10.1007/978-3-642-16483-5_5546
(2012) Sulcus. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3555. doi: 10.1007/978-3-642-16483-5_5559
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Muro, K. (2014). Convection-Enhanced Delivery. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1329-3
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DOI: https://doi.org/10.1007/978-3-642-27841-9_1329-3
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Publisher Name: Springer, Berlin, Heidelberg
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