Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Conjugated Linolenic Acids

  • Kazuo Miyashita
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1314-2

Synonyms

CLN

Definition

Conjugated linolenic acid (CLN) is a general term for the geometrical and positional isomers of octadecatrienoic (18:3) acid with three conjugated double bonds. Conjugated linolenic acids occur in several terrestrial plants (mainly seed oils). They include α-eleostearic acid (9 cis(c),11 trans(t),13t-18:3), catalpic acid (9t,11t,13c-18:3), punicic acid (9c,11t,13c-18:3), calendic acid (8t,10t,12c-18:3), and jacaric acid (8c,10t,12c-18:3) (Fig. 1). High contents of calendic acid, punicic acid, and α-eleostearic acid are found in seed oils of pot marigold, pomegranate, and tung/bitter gourd, respectively.

Keywords

Aberrant Crypt Focus Monocytic Leukemia Dietary Feeding Pomegranate Seed Punicic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Kohno H, Suzuki R, Noguchi R et al (2002) Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats. Jpn J Cancer Res 93:133–142CrossRefPubMedGoogle Scholar
  2. Narayan B, Hosokawa M, Miyashita K (2006) Occurrence of conjugated fatty acids in aquatic and terrestrial plants and their physiological effects. In: Shahidi F (ed) Nutraceutical and specialty lipids and their co-products. CRC Taylor & Francis, New York, pp 201–218CrossRefGoogle Scholar
  3. Suzuki R, Noguchi R, Ota T et al (2001) Cytotoxic effect of conjugated trienoic fatty acids on mouse tumor and human monocytic leukemia cells. Lipids 36:477–482CrossRefPubMedGoogle Scholar
  4. Yasui Y, Hosokawa M, Sahara T et al (2005) Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer Caco-2 cells. Prostaglandins Leukot Essent Fatty Acids 73:212–219CrossRefGoogle Scholar
  5. Yasui Y, Hosokawa M, Kohno H et al (2006) Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells. Anticancer Res 26:1855–1860PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Bioresources Chemistry, Faculty of Fisheries SciencesHokkaido UniversityHakodateJapan