Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Adult T-Cell Leukemia

  • Manfred Schwab
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_126-2

Synonyms

ATL

Definition

A leukemia of mature T lymphocytes (T cells) developing in adults, resulting from infection with the human T-cell leukemia virus (HTLV) and characterized by circulating malignant T lymphocytes, skin lesions, lymphadenopathy (enlarged lymph nodes), hepatosplenomegaly (enlarged liver and spleen), hypercalcemia (high blood calcium), lytic (“punched out”) bone lesions, and a tendency to infection. There are four categories of ATL, based on the aggressiveness of the disease – smoldering, chronic, lymphoma, and acute.

Cross-References

Keywords

Lymph Node Cancer Research Skin Lesion Bone Lesion Leukemia Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

See Also

  1. (2012) T cell. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3599. doi: 10.1007/978-3-642-16483-5_5645Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany