Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Class II Tumor Suppressor Genes

  • Christine Sers
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1201-2


Class II tumor suppressor genes encode proteins that function in the negative regulation of cell growth. The genes are downregulated in cancer without mutations or deletions in their coding regions. Downregulation is reversible indicating that gene and protein function can be reconstituted upon appropriate treatment.


The term “class II tumor suppressor gene” was invented in 1997 by Ruth Sager, who was the first to realize during the upcoming age of gene expression profiling that in human cancers many genes show reduced expression in tumors without being deleted or mutated. Accordingly, two classes of tumor suppressor genes were suggested: Class I tumor suppressor genes (tumor suppressor genes, TGS) that are lost in cancer due to mutation or deletion and class II tumor suppressor genes that are not altered at the DNA level but rather exhibit strongly reduced expression in tumors as compared with normal tissue.

Examples for classical, bona fide class I tumor...


Tumor Suppressor Tumor Suppressor Gene Ovarian Carcinoma Serine Protease Inhibitor Transcriptional Regulatory Complex 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institute of PathologyUniversity Medicine CharitéBerlinGermany