Living reference work entry
Cladribine is a purine nucleoside analog (PNA) synthesized by a simple substitution of a chlorine atom with a hydrogen atom at the position 2 of the purine ring of deoxyadenosine and resistant to deamination by adenosine deaminase (ADA) (Fig. 1).
KeywordsAcute Myeloid Leukemia Chronic Lymphocytic Leukemia Mantle Cell Lymphoma Mycosis Fungoides Hairy Cell Leukemia
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- Robak T, Robak P (2012) Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des 18:3373–88. http://www.ncbi.nlm.nih.gov/pubmed/20634380
- Sigal DS, Miller HJ, Schram ED, Saven A (2010) Beyond hairy cell: the activity of cladribine in other hematologic malignancies. Blood 116:2884–96. http://www.ncbi.nlm.nih.gov/pubmed/20634380
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