Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cladribine

  • Tadeusz Robak
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1198-3

Synonyms

Definition

Cladribine is a purine nucleoside analog (PNA) synthesized by a simple substitution of a chlorine atom with a hydrogen atom at the position 2 of the purine ring of deoxyadenosine and resistant to deamination by adenosine deaminase (ADA) (Fig. 1).

Keywords

Acute Myeloid Leukemia Chronic Lymphocytic Leukemia Mantle Cell Lymphoma Mycosis Fungoides Hairy Cell Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Barete S, Lortholary O, Damaj G, et al. (2015) Long-term efficacy and safety of cladribine (2-CdA) in adult patients with mastocytosis. Blood. pii: blood-2014-12-614743Google Scholar
  2. Beutler E (1992) Cladribine (2-chlorodeoxyadenosine). Lancet 340:952–956CrossRefPubMedGoogle Scholar
  3. Bryson H, Sorkin EM (1993) Cladribine. A review of its pharmacokinetic properties and therapeutic potential in haematological malignancies. Drugs 46:872–894CrossRefPubMedGoogle Scholar
  4. Freyer CW, Gupta N, Wetzler M, Wang ES (2015) Revisiting the role of cladribine in acute myeloid leukemia: an improvement on past accomplishments or more old news? Am J Hematol 90:62–72Google Scholar
  5. Pettitt AR (2003) Mechanism of action of purine analogues in chronic lymphocytic leukemia. Br J Haematol 121:692–702CrossRefPubMedGoogle Scholar
  6. Robak T (2001) Cladribine in the treatment of chronic lymphocytic leukemia. Leuk Lymphoma 40:551–564CrossRefPubMedGoogle Scholar
  7. Robak T, Lech-Marańda E, Korycka A (2006) Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity. Curr Med Chem 13:3165–3189CrossRefPubMedGoogle Scholar
  8. Robak T, Robak P (2012) Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des 18:3373–88. http://www.ncbi.nlm.nih.gov/pubmed/20634380
  9. Sigal DS, Miller HJ, Schram ED, Saven A (2010) Beyond hairy cell: the activity of cladribine in other hematologic malignancies. Blood 116:2884–96. http://www.ncbi.nlm.nih.gov/pubmed/20634380

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of HematologyMedical University of LodzLodzPoland