Cip-Interacting Zinc Finger Protein 1 Ciz1
Living reference work entry
Ciz1 is a member of the Matrin 3 protein family and also called NP94 (Nuclear Protein 94). At the N-terminal region, Ciz1 contains poly-glutamine repeats and glutamine rich regions. Additionally, the C-terminus contains three zinc-finger motifs, an acidic region and a matrin 3-homologous domain 3 (MH3 domain), which shows 40.4 % and 37.7 % identity (55.8 % and 64.2 % similarity) to NP220 and matrin 3 (two other members of the Matrin 3 family), respectively (Fig. 1). Ciz1 is expressed in a wide variety of tissues, with highest expression in pancreas, testis, kidney, and brain (with the highest expression in cerebellum) and is mainly localized in the nucleus. Ciz1 is expressed in a number of cell lines from multiple organ systems. None of the genes of Yeast, C. elegans or Drosophila showed any overall structural similarities to Ciz1, suggesting that Ciz1 is a unique protein only found in vertebrates.
KeywordsEstrogen Receptor Breast Cancer Cell Cell Cycle Progression Nuclear Matrix Transactivation Activity
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