Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cip-Interacting Zinc Finger Protein 1 Ciz1

  • Petra Den Hollander
  • Rakesh Kumar
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1171-2


Ciz1 is a member of the Matrin 3 protein family and also called NP94 (Nuclear Protein 94). At the N-terminal region, Ciz1 contains poly-glutamine repeats and glutamine rich regions. Additionally, the C-terminus contains three zinc-finger motifs, an acidic region and a matrin 3-homologous domain 3 (MH3 domain), which shows 40.4 % and 37.7 % identity (55.8 % and 64.2 % similarity) to NP220 and matrin 3 (two other members of the Matrin 3 family), respectively (Fig. 1). Ciz1 is expressed in a wide variety of tissues, with highest expression in pancreas, testis, kidney, and brain (with the highest expression in cerebellum) and is mainly localized in the nucleus. Ciz1 is expressed in a number of cell lines from multiple organ systems. None of the genes of Yeast, C. elegans or Drosophila showed any overall structural similarities to Ciz1, suggesting that Ciz1 is a unique protein only found in vertebrates.


Estrogen Receptor Breast Cancer Cell Cell Cycle Progression Nuclear Matrix Transactivation Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Coverley D, Marr J, Ainscough J (2005) Ciz1 promotes mammalian DNA replication. J Cell Sci 118:101–112PubMedCrossRefGoogle Scholar
  2. den Hollander P, Kumar R (2006) Dynein light chain 1 contributes to cell cycle progression by increasing cyclin-dependent kinase 2 activity in estrogen-stimulated cells. Cancer Res 66:5941–5949CrossRefGoogle Scholar
  3. den Hollander P, Rayala SK, Coverley D et al (2006) Ciz1, a novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action. Cancer Res 66:11021–11029CrossRefGoogle Scholar
  4. Mitsui K, Matsumoto A, Ohtsuka S et al (1999) Cloning and characterization of a novel p21(CiP1/Waf1)-interacting zinc finger protein, Ciz1. Biochem Biophys Res Commun 264:457–464PubMedCrossRefGoogle Scholar
  5. Warder DE, Keherly MJ (2003) Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0–2)YYAC. J Biomed Sci 10:406–417PubMedGoogle Scholar

See Also

  1. (2012) Cell Cycle. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 737. doi: 10.1007/978-3-642-16483-5_994Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Translational Molecular PathologyThe University of Texas MD Anderson Cancer CenterHouston, TXUSA
  2. 2.Department of Biochemistry and Molecular MedicineGeorge Washington UniversityWashington DCUSA