Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Adoptive Immunotherapy

  • Chrystal U. Louis
  • Helen E. Heslop
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_117-2



Immunotherapy; CIK; TIL; ATC; Lymphodepletion; CAR


Adoptive immunotherapy involves the passive transfer of cellular products designed to augment immunity against cancer or infections. To date, clinical trials have evaluated the efficacy of different cell populations including, but not limited to, unmanipulated leukocyte infusions from bone marrow donors, cytokine-induced T cells, lymphokine-activated killer cells, tumor-infiltrating lymphocytes, NK cells, and antigen-specific T cells.


Unmanipulated T Cells

Adoptive immunotherapy with unmanipulated donor lymphocyte infusion (DLI) has effectively treated patients with relapsed or residual disease after hematopoietic stem cell transplant (HSCT). DLI provides the host immune system an additional graft-versus-leukemia (GVL) effect and has been most successful in patients with chronic myeloid leukemia who relapse...


Acute Myeloid Leukemia Hematopoietic Stem Cell Transplant Chimeric Antigen Receptor Adoptive Immunotherapy Donor Lymphocyte Infusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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See Also

  1. (2012) Cytotoxic T lymphocytes. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1058. doi:10.1007/978-3-642-16483-5_1501Google Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Center for Cell and Gene Therapy, Baylor College of MedicineTexas Children’s Hospital, and The Methodist HospitalHoustonUSA