Chromosomal instability is the gain and/or loss of whole chromosomes or chromosomal segments at a higher rate in a population of cells, such as cancer cells, compared to their normal counterparts (normal cells). In some cancers, each cell within the tumor has a different chromosomal constitution (karyotype) due to chromosomal instability, which may be defined in practical terms as numerical and/or structural chromosomal alterations that vary from cell to cell. Although the terms chromosomal instability and genomic instability have been used interchangeably, this is technically incorrect, as they refer to different forms of genetic instability.
Chromosomal instability is a characteristic of cancer cells, especially solid tumors (rather than most hematologic (blood cell) malignancies). Several cellular mechanisms lead to numerical and structural chromosomal instability in cancer cells, including defects in (i) chromosomal distribution to the...
KeywordsChromosomal Instability Cell Cycle Checkpoint Penile Cancer Telomere Dysfunction Familial Pancreatic Cancer
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