Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

ADMET Screen

  • Christopher A. Lipinski
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_114-2

Definition

An ADMET screen is the application of a group of experimental assays to measure characteristics of a drug candidate in order to predict the absorption, distribution, metabolism, excretion, and toxicity properties of that drug.

Characteristics

ADMET is an abbreviation for absorption, distribution, metabolism, excretion, and toxicity. The term ADMET is often loosely used to denote those properties required for an orally active drug that are apart from the inherent biological activity of the drug. In a stricter sense, the term ADMET denotes the properties denoted by the abbreviation that are the focus of specialized knowledge in the fields of medicinal chemistry, drug metabolism, pharmaceutical sciences, and toxicology. The five properties in ADMET can be determined experimentally and to some degree computationally. As of 2007, all these properties can to variable degree be experimentally measured in manual or automated, medium to high capacity experimental assays (screens)....

Keywords

Biological Pump Drug Discovery Program Tract Content Parallel Artificial Membrane Permeability Assay ADMET Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Di L, Kerns EH (2005) Application of pharmaceutical profiling assays for optimization of drug-like properties. Curr Opin Drug Discov Devel 8(4):495–504PubMedGoogle Scholar
  2. Lipinski CA (2005) Filtering in drug discovery. In: Annual reports in computational chemistry, vol 1. Elsevier, Amsterdam, pp 155–168CrossRefGoogle Scholar
  3. Lipinski CA, Lombardo F, Dominy BW et al (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 23:3–25CrossRefGoogle Scholar
  4. Waterbeemd H (2003) Physico-chemical approaches to drug absorption. Methods Princ Med Chem 18(Drug Bioavailability):3–20Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Melior DiscoveryWaterfordUSA