Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Chromatin Remodeling

  • Yutaka Kondo
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1127-2

Synonyms

Definition

Chromatin remodeling is regulated by reorganization of nucleosome position by ATP-dependent nucleosome remodeling factors (ADNR) and covalent modifications of histone proteins. Because chromatin structure affects the binding of proteins including transcription factors to DNA, it is involved in many essential cellular processes.

Characteristics

Nucleosome (nucleosomes) consists of 147 bp DNA wrapped around the histone octamer comprising histone proteins, H2A, H2B, H3, and H4. Since the position of nucleosomes on DNA and the chromatin structure can affect the binding of proteins to DNA, chromatin remodeling is required for all the key processes such as gene expression (epigenetic gene silencing), DNA replication, repair, chromosomal recombination, and mitosis. ADNR factors, SWI-/SNF-type factors, which are the part of multiprotein complexes, shuffle the nucleosomes and change chromatin structure and organization...

Keywords

Histone Modification HDAC Inhibitor H3K9 Methylation Histone H3K9 Nucleosome Remodel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Cosgrove MS, Boeke JD, Wolberger C (2004) Regulated nucleosome mobility and the histone code. Nat Struct Mol Biol 11:1037–1043CrossRefPubMedGoogle Scholar
  2. Gibbons RJ (2005) Histone modifying and chromatin remodelling enzymes in cancer and dysplastic syndromes. Hum Mol Genet 14:R85–R92CrossRefPubMedGoogle Scholar
  3. Mellor J (2005) The dynamics of chromatin remodeling at promoters. Mol Cell 19:147–157CrossRefPubMedGoogle Scholar
  4. Yoo CB, Jones PA (2006) Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 5:37–50CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of EpigenomicsNagoya City University Graduate School of Medical SciencesNagoyaJapan