Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Chimeric Antigen Receptor (CAR)

  • Astrid Holzinger
  • Jennifer Makalowski
  • Hinrich Abken
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1096-4

Synonyms

Definition

Chimeric antigen receptors are recombinant transmembrane receptor molecules which are composed of an extracellular binding domain, mostly derived from an antibody, and an intracellular signaling domain, mostly derived from the T cell receptor (TCR) complex, to initiate immune cell activation upon engagement of the receptor ligand.

Characteristics

Chimeric antigen receptors (CARs) are designed to redirect immune cells, preferentially T cells, with predefined specificity toward target cells for the use in the adoptive immunotherapy. The strategy thereby takes advantage of the power of the immune cell response to target predefined cells in patients for the treatment of various diseases, mostly malignant diseases.

Technically, patient’s T cells are ex vivo engineered with the CAR by viral vector-mediated gene transfer, amplified to clinically relevant numbers and readministered to the patient. Currently, γ-retroviral and...

Keywords

Chronic Lymphocytic Leukemia Circulate Tumor Cell Chimeric Antigen Receptor Cognate Antigen Cognate Target 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

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  23. (2012) NK. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2529. doi:10.1007/978-3-642-16483-5_4096Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Astrid Holzinger
    • 1
  • Jennifer Makalowski
    • 1
  • Hinrich Abken
    • 1
  1. 1.Tumor Genetics, Clinic I Internal MedicineUniversity Hospital Cologne, and Center for Molecular Medicine Cologne, University of CologneCologneGermany