Chimeric Antigen Receptor on T Cells
A chimeric antigen receptor (CAR) consists of an extracellular antigen-binding exodomain, typically derived from a single-chain antibody fragment (scFv) of a monoclonal antibody (mAb), a spacer (such as an antibody Fc region), a transmembrane region, and one or more intracellular signaling endodomains, which can be genetically introduced into hematopoietic cells, such as T cells, to redirect specificity for a desired cell-surface antigen.
Background on Manipulating T-Cell Responses to Cancer
Adoptive transfer of tumor-specific T cells in mouse models can function as potent anticancer biological agents leading to the elimination of established malignancies. Continued advances in tumor immunology support the premise and promise for adoptive immunotherapyas a treatment for human malignancies. Yet, infusion of tumor-specific T cells has only been partially successful in clinical oncology trials. Indeed, most of these trials demonstrate the safety...