Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Adjuvant Chemoendocrine Therapy

  • Lorenzo Gianni
  • Alberto Ravaioli
  • Valentina Arcangeli
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_108-2



Adjuvant chemoendocrine therapy is a combination of chemotherapy and hormonal treatments that may be administered to patients after surgery for a nonmetastatic tumor with the goal of decreasing the risk of cancer recurrence.


Adjuvant chemoendocrine therapy is potentially useful for tumors which are responsive to both cytotoxic chemotherapy and hormonal interventions. The growth of these types of tumors is boosted by hormones and usually it may be limited not only by blocking these hormones but also by chemotherapy. Adjuvant chemoendocrine therapy is a standard treatment for early breast cancer, while it is experimental in prostate cancer, and it is not generally an option in other tumors with possible endocrine responsiveness such as endometrial cancer or ovarian cancer.

Breast Cancer

Surgery generally remains the first step for...


Breast Cancer Prostate Cancer Adjuvant Hormone Therapy Progesterone Receptor Expression Endocrine Responsiveness 
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  1. Castiglione-Gertsch M, O’Neill A, Price KN et al (2003) International Breast Cancer Study Group adjuvant chemotherapy followed by goserelin versus either modality alone for premenopausal lymph node-negative breast cancer: a randomized trial. J Natl Cancer Inst 95(24):1833–1846CrossRefPubMedGoogle Scholar
  2. Early Breast Cancer Trialist’ Collaborative Group (EBCTCG) (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365:1687–1717CrossRefGoogle Scholar
  3. Goldhirsh A, Wood WC, Gelber RD et al (2007) Progress and promise: highlight of International expert consensus on the primary therapy of early breast cancer. Ann Oncol 18(7):1133–1144CrossRefGoogle Scholar
  4. Stearns V, Davidson NE (2004) Adjuvant chemotherapy and chemoendocrine therapy. In: Harris JR, Lippman ME, Morrow M, Osborne CK (eds) Disease of the breast, 3rd edn. Lippincott Williams & Wilkins, Philadelphia, pp 893–919Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Lorenzo Gianni
    • 1
  • Alberto Ravaioli
    • 1
  • Valentina Arcangeli
    • 1
  1. 1.Department of OncologyInstituto Scientifico Romagnolo per lo s, Infermi HospitalRiminiItaly