Chemoprotectants are natural or synthetic chemical compounds which exhibit the ability to ameliorate, mimic, or inhibit the toxic or adverse effects of structurally different chemotherapeutic agents, radiation therapy, cytotoxic drugs, or naturally occurring toxins, without compromising the anticancer or antitumor potential of the chemotherapeutic drugs. Chemoprotectants should not affect the therapeutic efficacy of the chemotherapeutic agents, radiation, or drugs, disrupt the serum enzyme levels, or induce significant injury to the tissues/organs. These chemoprotectants include anticancer, antitumor, antiangiogenic, and antioxidant compounds and are used as an adjuvant in cancer chemotherapy.
According to the World Health Organization (WHO), cancer accounts for 7.6 million (or 13 %) of all deaths in 2005, and the incidence of cancer is expected to rise with an estimated 9 and 11.4 million deaths from cancer in 2015...
KeywordsGrape Seed Extract Tart Cherry Berry Extract Grape Seed Proanthocyanidins Ascorbyl Radical
- Bagchi D, Preuss HG (eds) (2004) Phytopharmaceuticals in cancer chemoprevention. CRC Press, Boca RatonGoogle Scholar