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Chemokine Receptor CXCR4

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 108 Accesses

Synonyms

CD184; Fusin; Receptor for CXCL12; Receptor for stromal cell-derived factor-1 alpha; SDF-1α

Definition

CXCR4 is a cell surface protein that acts as a receptor for the molecule CXCL12 (stromal cell-derived factor-1 alpha, SDF-1α). CXCL12 is one of a class of signaling molecules called chemokines that regulate the movement and other activities of cells throughout the body. Although CXCL12 and CXCR4 play major roles in regulating stem cells and cells of the immune system, CXCR4 is also found on many cancer cells and plays a part in metastasis, spread of the cancer cells being influenced by tissue levels of CXCL12.

Characteristics

Chemokines are a class of peptide mediators that play important roles in controlling cellular homing and migration both in embryonic development and in the regulation of cell populations in the adult. There are at least 40 different chemokines that fall into four classes depending upon their peptide structure. The different classes are “C,” “CC,” “CXC,”...

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See Also

  • (2012) Antibody. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 208. doi: 10.1007/978-3-642-16483-5_312

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  • (2012) Transcription. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3752. doi: 10.1007/978-3-642-16483-5_5899

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Dalhousie University, Halifax, NS, Canada

    Jonathan Blay

Authors
  1. Jonathan Blay
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Corresponding author

Correspondence to Jonathan Blay .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Blay, J. (2014). Chemokine Receptor CXCR4. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1067-3

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1067-3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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