Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Chemokine Receptor CXCR4

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1067-3

Synonyms

Definition

CXCR4 is a cell surface protein that acts as a receptor for the molecule CXCL12 (stromal cell-derived factor-1 alpha, SDF-1α). CXCL12 is one of a class of signaling molecules called chemokines that regulate the movement and other activities of cells throughout the body. Although CXCL12 and CXCR4 play major roles in regulating stem cells and cells of the immune system, CXCR4 is also found on many cancer cells and plays a part in metastasis, spread of the cancer cells being influenced by tissue levels of CXCL12.

Characteristics

Chemokines are a class of peptide mediators that play important roles in controlling cellular homing and migration both in embryonic development and in the regulation of cell populations in the adult. There are at least 40 different chemokines that fall into four classes depending upon their peptide structure. The different classes are “C,” “CC,” “CXC,”...

Keywords

Chemokine Receptor Chemokine Receptor CXCR4 CXCR4 Axis CXCR4 Protein CXCR4 Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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See Also

  1. (2012) Antibody. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 208. doi: 10.1007/978-3-642-16483-5_312Google Scholar
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  3. (2012) Chemotaxis. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 793. doi: 10.1007/978-3-642-16483-5_1081Google Scholar
  4. (2012) G-protein Couple Receptor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1587. doi: 10.1007/978-3-642-16483-5_2294Google Scholar
  5. (2012) Hematopoietic System. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1645. doi: 10.1007/978-3-642-16483-5_2621Google Scholar
  6. (2012) Ligands. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2040. doi: 10.1007/978-3-642-16483-5_3352Google Scholar
  7. (2012) Microenvironmental Niche. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2296. doi: 10.1007/978-3-642-16483-5_3721Google Scholar
  8. (2012) Stromal Cells. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3544. doi: 10.1007/978-3-642-16483-5_5535Google Scholar
  9. (2012) Transcription. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3752. doi: 10.1007/978-3-642-16483-5_5899Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of PharmacologyDalhousie UniversityHalifaxCanada