Encyclopedia of Astrobiology

Living Edition
| Editors: Muriel Gargaud, William M. Irvine, Ricardo Amils, Henderson James Cleaves, Daniele Pinti, José Cernicharo Quintanilla, Michel Viso

Combinatorial Library

  • Burckhard Seelig
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27833-4_5315-2


Combinatorial libraries are mixtures of large numbers of compounds. To study the origin and evolution of biomolecules such as nucleic acids or proteins, vast combinatorial libraries have been synthesized that contain up to 1015 different random RNA molecules or up to 1013 random polypeptides. These libraries are used in conjunction with in vitro selection techniques such as SELEX (systematic evolution of ligands by exponential enrichment) or mRNA display to test the hypothesis of the emergence of functional biomolecules from random sequence space.

See Also


Nucleic Acid Bioorganic Chemistry Systematic Evolution Random Sequence Sequence Space 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Biochemistry, Molecular Biology and Biophysics & BioTechnology InstituteUniversity of MinnesotaSt. PaulUSA