Encyclopedia of Astrobiology

Living Edition
| Editors: Muriel Gargaud, William M. Irvine, Ricardo Amils, Henderson James Cleaves, Daniele Pinti, José Cernicharo Quintanilla, Michel Viso

Disulfide Bond

  • Kensei Kobayashi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27833-4_449-4



A disulfide bond is a covalent bond between two sulfur atoms (-S-S-) formed by the coupling of two thiol (-SH) groups. Cysteine, one of the 20 protein amino acids, has a thiol group in its side chain and can easily be dimerized to cystine in aqueous solution by forming a disulfide bond. In many protein molecules, disulfide bonds between cysteine residues are essential for protein folding. Disulfide bonds in proteins are cleaved by heating or by the addition of reducing reagents, which leads to protein denaturation.

See Also


Aqueous Solution Bioorganic Chemistry Disulfide Bond Covalent Bond Cysteine Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Yokohama National UniversityYokohamaJapan