Encyclopedia of Astrobiology

Living Edition
| Editors: Muriel Gargaud, William M. Irvine, Ricardo Amils, Henderson James Cleaves, Daniele Pinti, José Cernicharo Quintanilla, Michel Viso

Wobble Hypothesis (Genetics)

  • Juli Peretó
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27833-4_1692-2

Definition

The Wobble hypothesis proposes that normal base pairing can occur between nitrogen bases in positions 1 and 2 of the codon and the corresponding bases (3 and 2) in the anticodon. Actually, the base 1 in anticodon can form non-Watson-Crick base pairing with the third position of the codon. The hypothesis is applicable to most (not all) tRNAs.

History

Hypothesis proposed by Francis Crick in 1966 to explain the observed degeneracy in the third position of a codon.

See Also

Keywords

Base Pairing Bioorganic Chemistry Genetic Code Nitrogen Base Normal Base 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institut Cavanilles de Biodiversitat i Biologia EvolutivaUniversitat de ValènciaValènciaSpain