Encyclopedia of Astrobiology

Living Edition
| Editors: Muriel Gargaud, William M. Irvine, Ricardo Amils, Henderson James Cleaves, Daniele Pinti, José Cernicharo Quintanilla, Michel Viso

Mutagen

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27833-4_1034-3

Definition

A mutagen is a physical, chemical, or biological agent able to increase the occurrence of mutations above the spontaneous level. Mutations produced by the action of mutagens are called induced mutations. The effect of most mutagens is due to their ability to modify a particular nucleic acid base or to become incorporated into the nucleic acid. As a high amount of mutations have deleterious effects on fitness, exposure to mutagens usually has negative consequences. Nonetheless, at early evolutionary stages, certain environmental mutagens could have had a positive effect, increasing the extent of genetic diversity accessible to natural selection.

Overview

Among chemical mutagens, the most important are nucleic acid base analogs – which due to their similitude with natural bases can be incorporated into DNA or RNA during replication – and compounds that produce chemical alterations in the bases (Drake and Baltz 1976). The result in both cases is the induction of erroneous base...

Keywords

Base analogs Evolution Genetic damage Genetic diversity Mutation Radiation 
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References and Further Reading

  1. Drake JW, Baltz RH (1976) The biochemistry of mutagenesis. Annu Rev Biochem 45:11–37CrossRefGoogle Scholar
  2. Friedberg EC, Walker GC, Siede W, Wood RD (2005) DNA repair and mutagenesis. ASM Press, Washington, DCGoogle Scholar
  3. Leib-Mösch C, Seifarth W (1995) Evolution and biological significance of human retroelements. Virus Genes 11:133–145CrossRefGoogle Scholar
  4. Rothschild LJ, Cockell CS (1999) Radiation: microbial evolution, ecology, and relevance to Mars missions. Mutat Res 430:281–291CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Molecular Evolution LaboratoyCentro de Astrobiología (CSIC-INTA)Torrejón de Ardoz, MadridSpain