Impaired Wound Repair and Delayed Angiogenesis

  • Megan E. Schrementi
  • Matthew J. Ranzer
  • Luisa A. DiPietro
Living reference work entry

Abstract

As the skin ages, the normal signs of aging such as alterations in pigmentation and increased wrinkling become more obvious. Although these changes appear to be mainly cosmetic, under the epidermis there is a gradual change in resident cell populations and loss of function. These changes result in a decreased ability to regulate homeostasis and underlie the delay in skin healing that occurs with age. Changes in hemostasis cause blood clotting to occur slowly and influence the healing progression. Likewise, age-related inflammatory changes in wounds most influence the latter phases of repair, including cellular proliferation and remodeling. Alterations in the stem cell populations that provide new cells to the healing wound occur, since this vital cell population is diminished in aged individuals. Thus, when a wound occurs, the normal stages of wound healing will proceed, although at an altered rate. In unfavorable conditions, this can result in an increased likelihood of infection or ulcer formation. Additionally, diseases associated with aging such as diabetes and vascular disease can amplify the alterations in wound healing, increasing the likelihood of wound complications. As research in the aged skin continues, the changes in the skin that affect wounding will continue to be elucidated, giving rise to new treatments for this growing patient population.

Keywords

Wound Healing Hair Follicle Sweat Gland Aged Mouse Stem Cell Population 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Megan E. Schrementi
    • 1
    • 2
  • Matthew J. Ranzer
    • 1
    • 2
  • Luisa A. DiPietro
    • 1
    • 2
  1. 1.Center for Wound Healing and Tissue Regeneration, College of DentistryUniversity of Illinois at ChicagoChicagoUSA
  2. 2.Department of BiologyDePaul UniversityChicagoUSA

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