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Corneocyte Size and Cell Renewal: Effects of Aging and Sex Hormones

  • Razvigor Darlenski
  • Enzo Berardesca
  • Joachim W. Fluhr
Living reference work entry

Abstract

Epidermal barrier function resides almost entirely in the outermost skin layer – stratum corneum (SC). Aging process results in certain structural and functional changes in SC morphology. The epidermis shows a linear decrease in thickness with age. The reduction in epidermal population size suggests that there may be also a decrease in the rate on production of epidermal cells and the apparent lengthening of the SC renewal time. The lengthening of the turnover implies a reduction in the desquamation rate, but this is not as large as thought. The reason for this might be the increase of corneocyte size during aging. There is a correlation and an inverse relationship between SC turnover and dimensions of corneocytes.

Sex hormones exhibit certain effects on SC structure and functions. A decreased sebum content of the forehead in menopausal women and higher SC hydration of the forehead in late menopausal women were observed. SC sphingolipid content and synthesis were decreased with the decrease of the effect of sex hormones with age. Aged epidermal permeability barrier shows decreased cohesion as well as delayed barrier repair with age under stress conditions. Significantly smaller corneocytes in premenopausal women vs. postmenopausal women or men were witnessed and are likely to be attributed to the different levels of female sex hormones. These effects were decreased when hormone replacement therapy was introduced in postmenopausal women.

Keywords

Stratum Corneum Hormonal Replacement Therapy Dansyl Chloride Cholesterol Sulfate Facial Wrinkle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Landmann L. The epidermal permeability barrier. Anat Embryol (Berl). 1988;178(1):1–13.CrossRefGoogle Scholar
  2. 2.
    Steven AC, Steinert PM. Protein composition of cornified cell envelopes of epidermal keratinocytes. J Cell Sci. 1994;107(Pt 2):693–700.PubMedGoogle Scholar
  3. 3.
    Swartzendruber DC, et al. Evidence that the corneocyte has a chemically bound lipid envelope. J Invest Dermatol. 1987;88(6):709–13.CrossRefPubMedGoogle Scholar
  4. 4.
    Wertz PW, Downing DT. Covalently bound omega-hydroxyacylsphingosine in the stratum corneum. Biochim Biophys Acta. 1987;917(1):108–11.CrossRefPubMedGoogle Scholar
  5. 5.
    Haftek M. ‘Memory’ of the stratum corneum: exploration of the epidermis’ past. Br J Dermatol. 2014;171 Suppl 3:6–9.CrossRefPubMedGoogle Scholar
  6. 6.
    Fluhr JW, et al. Development and organization of human stratum corneum after birth: electron microscopy isotropy score and immunocytochemical corneocyte labelling as epidermal maturation’s markers in infancy. Br J Dermatol. 2014;171(5):978–86.CrossRefPubMedGoogle Scholar
  7. 7.
    Chu M, Kollias N. Documentation of normal stratum corneum scaling in an average population: features of differences among age, ethnicity and body site. Br J Dermatol. 2011;164(3):497–507.PubMedGoogle Scholar
  8. 8.
    Furukawa F, et al. Effects of adenosine 5′-monophosphate on epidermal turnover. Arch Dermatol Res. 2008;300(9):485–93.CrossRefPubMedGoogle Scholar
  9. 9.
    Kligman AM. Perspectives and problems in cutaneous gerontology. J Invest Dermatol. 1979;73(1):39–46.CrossRefPubMedGoogle Scholar
  10. 10.
    Marks R. The effects of photoageing and intrinsic ageing on epidermal structure and function. G Ital Chir Dermatol Oncol. 1987;2:252–63.Google Scholar
  11. 11.
    Marks R. The epidermal engine: a commentary on epidermopoiesis, desquamation and their interrelationships. Int J Cosmet Sci. 1986;8(3):135–44.CrossRefPubMedGoogle Scholar
  12. 12.
    Jansen LH, Hojyo-Tomoko MT, Kligman AM. Improved fluorescence staining technique for estimating turnover of the human stratum corneum. Br J Dermatol. 1974;90(1):9–12.CrossRefPubMedGoogle Scholar
  13. 13.
    Roberts D, Marks R. The determination of regional and age variations in the rate of desquamation: a comparison of four techniques. J Invest Dermatol. 1980;74(1):13–6.CrossRefPubMedGoogle Scholar
  14. 14.
    Marks R. Measurement of biological ageing in human epidermis. Br J Dermatol. 1981;104(6):627–33.CrossRefPubMedGoogle Scholar
  15. 15.
    Grove G, et al. Use of nonintrusive tests to monitor age associated changes in human skin. J Soc Cosmet Chem. 1981;32:15–26.Google Scholar
  16. 16.
    Leveque JL, et al. In vivo studies of the evolution of physical properties of the human skin with age. Int J Dermatol. 1984;23(5):322–9.CrossRefPubMedGoogle Scholar
  17. 17.
    Marks R, Nicholls S, King CS. Studies on isolated corneocytes. Int J Cosmet Sci. 1981;3(6):251–9.CrossRefPubMedGoogle Scholar
  18. 18.
    Plewig G. Regional differences of cell sizes in the human stratum corneum. II. Effects of sex and age. J Invest Dermatol. 1970;54(1):19–23.CrossRefPubMedGoogle Scholar
  19. 19.
    Corcuff P, Leveque JL. Corneocyte changes after acute UV irradiation and chronic solar exposure. Photodermatol. 1988;5(3):110–5.PubMedGoogle Scholar
  20. 20.
    Hermann S, Scheuber E, Plewig G. Exfoliative cytology: effects of seasons. In: Marks R, Plewig G, editors. Stratum corneum. Berlin: Springer; 1983. p. 181–5.CrossRefGoogle Scholar
  21. 21.
    Leveque J, et al. Influence of chronic sun exposure on some biophysical parameters of the human skin; an in vivo study. J Cutan Aging Cosmet Dermatol. 1988;1:123–7.Google Scholar
  22. 22.
    Ohta H, et al. Relationship between dermato-physiological changes and hormonal status in pre-, peri-, and postmenopausal women. Maturitas. 1998;30(1):55–62.CrossRefPubMedGoogle Scholar
  23. 23.
    Denda M, et al. Age- and sex-dependent change in stratum corneum sphingolipids. Arch Dermatol Res. 1993;285(7):415–7.CrossRefPubMedGoogle Scholar
  24. 24.
    Roshan S, Nader S, Orlander P. Review: ageing and hormones. Eur J Clin Invest. 1999;29(3):210–3.CrossRefPubMedGoogle Scholar
  25. 25.
    Tazuke S, Khaw KT, Barrett-Connor E. Exogenous estrogen and endogenous sex hormones. Medicine (Baltimore). 1992;71(1):44–51.Google Scholar
  26. 26.
    Sauerbronn AV, et al. The effects of systemic hormonal replacement therapy on the skin of postmenopausal women. Int J Gynaecol Obstet. 2000;68(1):35–41.CrossRefPubMedGoogle Scholar
  27. 27.
    Ghadially R, et al. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest. 1995;95(5):2281–90.PubMedCentralCrossRefPubMedGoogle Scholar
  28. 28.
    Reed JT, Ghadially R, Elias PM. Skin type, but neither race nor gender, influence epidermal permeability barrier function. Arch Dermatol. 1995;131(10):1134–8.CrossRefPubMedGoogle Scholar
  29. 29.
    Fluhr JW, et al. Differences in corneocyte surface area in pre- and post-menopausal women. Assessment with the noninvasive videomicroscopic imaging of corneocytes method (VIC) under basal conditions. Skin Pharmacol Appl Skin Physiol. 2001;14 Suppl 1:10–6.CrossRefPubMedGoogle Scholar
  30. 30.
    Pierard GE, et al. Effect of hormone replacement therapy for menopause on the mechanical properties of skin. J Am Geriatr Soc. 1995;43(6):662–5.CrossRefPubMedGoogle Scholar
  31. 31.
    Pierard-Franchimont C, et al. Skin water-holding capacity and transdermal estrogen therapy for menopause: a pilot study. Maturitas. 1995;22(2):151–4.CrossRefPubMedGoogle Scholar
  32. 32.
    Guinot C, et al. Effect of hormonal replacement therapy on skin biophysical properties of menopausal women. Skin Res Technol. 2005;11(3):201–4.CrossRefPubMedGoogle Scholar
  33. 33.
    Chen L, et al. The use of high-frequency diagnostic ultrasound to investigate the effect of hormone replacement therapy on skin thickness. Skin Res Technol. 2001;7(2):95–7.CrossRefPubMedGoogle Scholar
  34. 34.
    Youn CS, et al. Effect of pregnancy and menopause on facial wrinkling in women. Acta Derm Venereol. 2003;83(6):419–24.CrossRefPubMedGoogle Scholar
  35. 35.
    Batisse D, Giron F, Leveque JL. Capacitance imaging of the skin surface. Skin Res Technol. 2006;12(2):99–104.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Razvigor Darlenski
    • 1
  • Enzo Berardesca
    • 2
  • Joachim W. Fluhr
    • 3
  1. 1.Department of Dermatology and VenereologyTokuda Hospital SofiaSofiaBulgaria
  2. 2.San Gallicano Dermatological InstituteRomeItaly
  3. 3.Department of DermatologyCharité University ClinicBerlinGermany

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