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Fibulin-5 Deposition in Human Skin: Decrease with Aging and UVB Exposure and Increase in Solar Elastosis

  • Satoshi Amano
Living reference work entry

Abstract

The aim of this study was to explore the changes of fibulin-5 and elastic fibers during the skin aging process and to clarify the role of fibulin-5 in the formation of elastic fibers. We analyzed fibulin-5 expression in both normal and actinically damaged skins compared with expression of elastin, fibulin-2, and fibrillin-1. Fibulin-5 decreased in an age-dependent manner in the reticular dermis, and the reduction was enhanced by UVB irradiation. Moreover, acute UVB irradiation markedly reduced fibulin-5. However, fibulin-5 was also found to accumulate in solar elastosis, together with other elastic fiber components, such as elastin, fibulin-2, and fibrillin-1. On the other hand, an increase of fibulin-5 synthesis by dermal fibroblasts was effective for elastic fiber regeneration. Fibulin-5 could facilitate the elastic fiber assembly in in vitro condition These results indicated that fibulin-5 is an early marker of skin aging and that the early loss of fibulin-5 in the dermis may prefigure the age-dependent reduction of other elastic fiber components and furthermore that fibulin-5 may be effective on the repair of elastic fiber.

Keywords

Elastic Fiber Skin Aging Papillary Dermis Reticular Dermis Cutis Laxa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Shiseido Research CenterYokohamaJapan

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