Fibulin-5 Deposition in Human Skin: Decrease with Aging and UVB Exposure and Increase in Solar Elastosis

  • Satoshi Amano
Living reference work entry


The aim of this study was to explore the changes of fibulin-5 and elastic fibers during the skin aging process and to clarify the role of fibulin-5 in the formation of elastic fibers. We analyzed fibulin-5 expression in both normal and actinically damaged skins compared with expression of elastin, fibulin-2, and fibrillin-1. Fibulin-5 decreased in an age-dependent manner in the reticular dermis, and the reduction was enhanced by UVB irradiation. Moreover, acute UVB irradiation markedly reduced fibulin-5. However, fibulin-5 was also found to accumulate in solar elastosis, together with other elastic fiber components, such as elastin, fibulin-2, and fibrillin-1. On the other hand, an increase of fibulin-5 synthesis by dermal fibroblasts was effective for elastic fiber regeneration. Fibulin-5 could facilitate the elastic fiber assembly in in vitro condition These results indicated that fibulin-5 is an early marker of skin aging and that the early loss of fibulin-5 in the dermis may prefigure the age-dependent reduction of other elastic fiber components and furthermore that fibulin-5 may be effective on the repair of elastic fiber.


Elastic Fiber Skin Aging Papillary Dermis Reticular Dermis Cutis Laxa 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Shiseido Research CenterYokohamaJapan

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