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Pathology of Aging Skin

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Textbook of Aging Skin

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Abstract

Human skin is a dynamic complex organ functioning as both a physical and biochemical barrier to protect the human body from water loss and environmental insults while providing multiple life-sustaining physiological functions. Skin undergoes a chronological aging process accompanied by physical changes, clinical manifestations, and psychological consequences. At the level of epidermis, defects in stratum corneum integrity and subsequent barrier dysfunction following external insults are observed in aged humans. An increase in pH in the stratum corneum of aging skin may decrease the concentration of lipids leading to defects in stratum corneum homeostasis and epidermal barrier function. At the level of upper dermis, fragmentation and reduction in collagen and elastin as well as a collapse in fibroblast morphology underline the majority of the undesired dermal clinical manifestations including the loss of dermal mechanical tension resulting in skin laxity and fine wrinkles. Both intracellular factors including attack by reactive oxygen species, DNA telomere shortening, and damage to DNA repair enzymes and intercellular microenvironmental factors including breakdown of the extracellular matrix and microinflammation are considered important in the process of skin aging.

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Authors and Affiliations

  1. The Procter & Gamble Company, Central Product Safety, 11530 Reed Hartman Road, Cincinnati, OH, 45241, USA

    Qunshan Jia & J. Frank Nash

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  1. Qunshan Jia
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  2. J. Frank Nash
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Correspondence to Qunshan Jia .

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Editors and Affiliations

  1. Procter & Gamble Co., Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Procter & Gamble Co., Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department Dermatology, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Howard I. Maibach

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Jia, Q., Nash, J.F. (2015). Pathology of Aging Skin. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27814-3_28-2

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  • DOI: https://doi.org/10.1007/978-3-642-27814-3_28-2

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