Hyaluronan and the Process of Aging in Skin

  • Diana Alyce Rivers
  • Robert Stern
Living reference work entry


Hyaluronan is a major component of the extracellular matrix of skin and important in the metabolism of both epidermis and dermis. Hyaluronan is responsible for hydration, nutrient exchange, and protects against free radical damage via a multitude of signaling pathways. It is also involved in basic biological processes such as cell renewal, differentiation, and motility. An overview is provided here that provides recent information, bringing up-to-date advances in hyaluronan and matrix biology with a particular emphasis on the process of aging in human skin. The differences between hyaluronan applied exogenously and that occurring naturally in the body are articulated. A brief history is also provided of various commercial hyaluronan-containing skin-care products, including topical applications, as injectable skin fillers, and in nanoparticle delivery systems.


Basal Lamina Dermal Fibroblast Lamellar Body Alopecia Areata Mandelic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.The Department of Basic Biomedical SciencesTouro College of Osteopathic MedicineNew YorkUSA

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