Influence of Exogenous Factors on Skin Aging

  • Avani Ahuja
  • Neha Singh
  • Prashant Gupta
  • Shivangi Mishra
  • Vibha Rani
Living reference work entry


Being the most superficial organ, skin is constantly exposed to various insults in the surrounding majorly including ultraviolet rays (UVR), air pollutants, heavy metals, and cigarette smoke. Additionally, chemical ingredients in most of the cosmetic and dermatological products applied on the skin for its maintenance and protection negatively impact by contributing in the process of degeneration of skin cells. These exogenous factors further enhance the release of reactive oxygen species (ROS) triggering the activation of matrix metalloproteinases (MMPs) and inflammatory responses, hence damaging the extracellular matrix (ECM) components by stimulating skin aging through intrinsic factors. Certain UVR-sensitive genes also get activated by ROS, resulting in DNA damage and with compromised repair pathway, the cell undergoes the process of apoptosis. The alterations a cell undergoes after being exposed to environmental toxins contribute in its morphological and physiological deterioration resulting in dark spots, wrinkles, decreased elasticity, and dryness: characterizing aged skin. The present chapter discusses some of the major environmental pollutants and chemicals which influence the process of accelerated skin aging.


Sodium Lauryl Sulfate Premature Aging Skin Aging Cosmetic Ingredient Tocopheryl Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations


Extracellular matrix


Hormone replacement therapy


Infra –red radiation


Matrix metalloproteinases


Matrix metalloproteinase-1


Metal working fluids


Nitrogen oxide


Poly-aromatic hydrocarbons


Particulate matter


Reactive nitrogen species


Reactive nitrogen species


Reactive oxygen species


Reactive oxygen species


2,3 7, 8-tetrachlorodibenzo-p-dioxin


Ultraviolet radiation


Ultraviolet radiation


Volatile organic compounds


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Avani Ahuja
    • 1
  • Neha Singh
    • 1
  • Prashant Gupta
    • 1
  • Shivangi Mishra
    • 1
  • Vibha Rani
    • 1
  1. 1.Department of BiotechnologyJaypee Institute of Information TechnologyNoidaIndia

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