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Aging Skin: Nourishing from Out-In. Lessons from Wound Healing

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Abstract

Skin lesion therapy, peculiarly in the elderly, cannot be isolated from understanding that the skin is an important organ consisting of different tissues. Furthermore, dermis health is fundamental for epidermis integrity, and so adequate nourishment is mandatory in maintaining skin integrity. The dermis nourishes the epidermis, and a healthy epidermis protects the dermis from the environment, so nourishing the dermis through the epidermal barrier is a technical problem yet to be resolved. This is also a consequence of the laws and regulations restricting cosmetics, which cannot have properties that pass the epidermal layer. There is higher investment in cosmetics than in the pharmaceutical industry dealing with skin therapies, because the costs of drug registration are enormous and the field is unprofitable. Still, wound healing may be seen as an opportunity to “feed” the dermis directly. It could also verify whether providing substrates could promote efficient healing and test optimal skin integrity maintenance, if not skin rejuvenation, in an ever aging population.

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Author information

Authors and Affiliations

  1. Department of Clinical and Experimental Sciences, Division of Human Anatomy and Physiopathology, University of Brescia, Brescia, Italy

    Giovanni Corsetti & Claudia Romano

  2. Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy

    Vincenzo Flati & Anna Rufo

  3. “S. Maugeri Foundation”, IRCCS, Cardiology Rehabilitative Division, Medical Centre of Lumezzane, Brescia, Italy

    Evasio Pasini

  4. Plastic and Reconstructive Surgery and Burns Centre, Brotzu Hospital, Cagliari, Italy

    Raimondo Pinna

  5. Department of Internal Medicine and Community Health, University of Milan, Via della Pace, 15, 20122, Milan, Italy

    Francesco S. Dioguardi

Authors
  1. Giovanni Corsetti
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  2. Vincenzo Flati
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  3. Evasio Pasini
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  4. Claudia Romano
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  5. Anna Rufo
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  6. Raimondo Pinna
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  7. Francesco S. Dioguardi
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Corresponding author

Correspondence to Francesco S. Dioguardi .

Editor information

Editors and Affiliations

  1. Procter & Gamble Co., Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Procter & Gamble Co., Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department Dermatology, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Howard I. Maibach

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© 2015 Springer-Verlag Berlin Heidelberg

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Corsetti, G. et al. (2015). Aging Skin: Nourishing from Out-In. Lessons from Wound Healing. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27814-3_136-1

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  • DOI: https://doi.org/10.1007/978-3-642-27814-3_136-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27814-3

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