Topical Growth Factors for Skin Rejuvenation
Growth factors play a key role in the regulation of numerous cell processes including wound healing. More recently, they have been recognized also for use in skin rejuvenation. Aged skin reveals a similarly altered growth factor response as a chronic wound. Growth factors may reduce signs of skin aging due to their capacity to promote dermal fibroblast proliferation and to stimulate extracellular matrix formation. Growth factor products for skin rejuvenation can contain either recombinant growth factors, growth factors as part of conditioned cell culture media, or growth factors as part of cell lysates. Numerous randomized controlled clinical trials demonstrated the good tolerability and efficacy of those products. Today, there is evidence that the signs of aging skin may be best improved with a balanced mixture of growth factors.
KeywordsGrowth factor Skin aging Rejuvenation Wound healing Fetal skin repair Scar Extracellular matrix Collagen Transforming growth factor-beta Conditioned medium Cell lysate Fibroblast Peptide Matrikine Clinical study
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