Definition
Upon vascular injury, the dynamic hemostasis system engages platelets and cell-derived microparticles, the stationary vessel wall, as well as humoral and cell-associated factors of blood coagulation and fibrinolysis to ensure a proper wound-healing response under the conditions of continuous and variable blood flow. These spatiotemporally regulated reactions prevent life-threatening bleeding, protect against microbial invaders, and initiate wound-healing and tissue repair mechanisms. Thus, hemostasis can be considered as part of the innate immune system (Engelmann and Massberg 2013).
Characteristics
Definition of Components Involved
As the innermost monolayer of cells, the vascular endothelium covers all blood vessels and functions as permeability barrier between the blood and the underlying tissues. In different vascular beds, the particular phenotype of the endothelium varies between continuous,...
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Preissner, K.T. (2014). Blood Coagulation. In: Vohr, HW. (eds) Encyclopedia of Immunotoxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27786-3_182-2
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DOI: https://doi.org/10.1007/978-3-642-27786-3_182-2
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27786-3
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