Living Reference Work Entry

Encyclopedia of Psychopharmacology

pp 1-6

Date: Latest Version

Electrochemical Techniques and Advances in Psychopharmacology

  • Lynette C. DawsAffiliated withDepartment of Physiology and Pharmacology, University of Texas Health Science Center at San Antonio Email author 
  • , Anne M. AndrewsAffiliated withSemel Institute for Neuroscience and Human Behavior, Hatos Center for Neuropharmacology, California NanoSystems Institute, University of California
  • , Greg A. GerhardtAffiliated withDepartment of Anatomy and Neurobiology, Morris K. Udall Parkinson’s Disease Research Center of Excellence, Center for Microelectrode Technology, University of Kentucky Medical Center


Amperometry; Fast-scan cyclic voltammetry; High-speed chronoamperometry


Electrochemical Techniques: A group of analytical methods based on measuring the current produced by oxidation and/or reduction of electroactive molecules at an electrode or microelectrode surface. Loss or gain of electrons, respectively, occurs in response to an applied potential at the working electrode with respect to a reference electrode: commonly called voltammetry, amperometry, chronoamperometry, or fast-scan cyclic voltammetry due to the way the voltage is applied. The resulting current produced by the oxidation/reduction of analytes is proportional to analyte concentrations at the electrode surface. Historically, electrochemical techniques have been utilized to study chemical reactions, but more recently, they have been used to measure the concentrations of neurotransmitters and other endogenous substances in biological systems. Considerable research has been carried out over the last thre ...

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