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Nicotinic Agonists and Antagonists

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References

  • Albuquerque EX, Pereira EF, Alkondon M, Rogers SW (2009) Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev 89:73–120

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Bencherif M, Lippiello PM, Lucas R, Marrero MB (2011) Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases. Cell Mol Life Sci 68:931–949

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Changeux JP (2010) Nicotine addiction and nicotinic receptors: lessons from genetically modified mice. Nat Rev Neurosci 11:389–401

    Article  CAS  PubMed  Google Scholar 

  • D’Souza MS, Markou A (2011) Neuronal mechanisms underlying development of nicotine dependence: implications for novel smoking-cessation treatments. Addict Sci Clin Pract 6:4–16

    PubMed Central  PubMed  Google Scholar 

  • Gao B, Hierl M, Clarkin K, Juan T, Nguyen H, Valk M, Deng H, Guo W, Lehto SG, Matson D, McDermott JS, Knop J, Gaida K, Cao L, Waldon D, Albrecht BK, Boezio AA, Copeland KW, Harmange JC, Springer SK, Malmberg AB, McDonough SI (2010) Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain. Pain 149:33–49

    Article  CAS  PubMed  Google Scholar 

  • Govind AP, Walsh H, Green WN (2012) Nicotine-induced upregulation of native neuronal nicotinic receptors is caused by multiple mechanisms. J Neurosci 32:2227–2238

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hajós M, Rogers BN (2010) Targeting alpha7 nicotinic acetylcholine receptors in the treatment of schizophrenia. Curr Pharm Des 16:538–554

    Article  PubMed  Google Scholar 

  • Hurst R, Rollema H, Bertrand D (2013) Nicotinic acetylcholine receptors: from basic science to therapeutics. Pharmacol Therapeutics 137:22–54

    Article  CAS  Google Scholar 

  • Lee CH, Zhu C, Malysz J, Campbell T, Shaughnessy T, Honore P, Polakowski J, Gopalakrishnan M (2011) α4β2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of α4β2 nAChR agonists in pain. Biochem Pharmacol 82:959–966

    Article  CAS  PubMed  Google Scholar 

  • Mineur YS, Picciotto MR (2010) Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis. Trends Pharmacol Sci 31:580–586

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Philip NS, Carpenter LL, Tyrka AR, Price LH (2010) Nicotinic acetylcholine receptors and depression: a review of the preclinical and clinical literature. Psychopharmacology (Berl) 212:1–12

    Article  CAS  Google Scholar 

  • Posadas I, López-Hernández B, Ceña V (2013) Nicotinic receptors in neurodegeneration. Curr Neuropharmacol 11:298–314

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Quik M, O’Leary K, Tanner CM (2013) Nicotine and Parkinson’s disease: implications for therapy. Mov Disord 23:1641–1652

    Article  Google Scholar 

  • Rollema H, Bertrand D, Hurst RS (2010) Nicotinic agonists and antagonists. In: Encyclopedia of psychopharmacology. Springer, Berlin/Heidelberg, pp 887–899

    Google Scholar 

  • Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamure T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton SA (2013) Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. PNAS USA 110:27. doi:10.1073/pnas.130683211

    Article  Google Scholar 

  • Taly A, Corringer PJ, Guedin D, Lestage P, Changeux JP (2009) Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov 8:733–750

    Article  CAS  PubMed  Google Scholar 

  • Umana IC, Daniele CA, McGehee DS (2013) Neuronal nicotinic receptors as analgesic targets: It’s a winding road. Biochem Pharmacol 86:1208–1214

    Article  CAS  PubMed  Google Scholar 

  • Wallace TL, Porter RH (2011) Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease. Biochem Pharmacol 82:891–903

    Article  CAS  PubMed  Google Scholar 

  • Wang HY, Bakshi K, Shen C, Frankfurt M, Trocmé-Thibierge C, Morain P (2010) S 24795 limits beta-amyloid-alpha7 nicotinic receptor interaction and reduces Alzheimer’s disease-like pathologies. Biol Psychiatry 67:522–530

    Article  CAS  PubMed  Google Scholar 

  • Weber ML, Hofland CM, Shaffer CL, Flik G, Cremers T, Hurst RS, Rollema H (2013) Therapeutic doses of antidepressants are projected not to inhibit human α4β2 nicotinic acetylcholine receptors. Neuropharmacology 72:88–95

    Article  CAS  PubMed  Google Scholar 

  • Wilens TE, Decker MW (2007) Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: focus on cognition. Biochem Pharmacol 74:1212–1223

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Zhang J, Xiao YD, Jordan KG, Hammond PS, Van Dyke KM, Mazurov AA, Speake JD, Lippiello PM, James JW, Letchworth SR, Bencherif M, Hauser TA (2012) Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: correlation with desensitization of α4β2* receptors. Eur J Pharm Sci 47(5):813–823

    Article  CAS  PubMed  Google Scholar 

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Rollema, H., Bertrand, D., Hurst, R.S. (2014). Nicotinic Agonists and Antagonists. In: Stolerman, I., Price, L. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27772-6_304-2

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  • DOI: https://doi.org/10.1007/978-3-642-27772-6_304-2

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