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Encyclopedia of Psychopharmacology pp 1–4Cite as

Liquid Diet for Administering Alcohol

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Definition

This is a technique for feeding alcohol (ethanol) as part of a liquid diet. The technique helps to mimic in experimental animals the effects of chronic alcohol intake in man and is used in research on alcohol effects in experimental animals, especially rodents. It has been used for more than 40 years in many experimental studies that investigate and model the effects of alcohol abuse and dependence in animals.

Proper controls and dietary adequacy pose significant challenges in studies on chronic exposure to alcohol in rodents. Thus, a suitable animal model that mimics the effects of chronic alcohol intake in man has long been sought. The technique of feeding ethanol as part of a totally liquid diet was first reported in 1963 (Lieber et al. 1963). Then, the liquid diet technique became the most preferred and practical method to induce physical dependence on alcohol experimentally since aversions to alcohol can be overcome and the intake is sufficient to sustain high daily...

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References

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Authors and Affiliations

  1. Department of Medical Pharmacology, Faculty of Medicine, Psychopharmacology Research Unit, Gulhane Military Medical Academy, Etlik, Ankara, 06018, Turkey

    Tayfun Uzbay

  2. Instituto de Psicologia, Universidade Federal Do Rio Grande do Sul, Rua Ramiro Barcellos 2600, sola 105, Porto Alegre, RS, 90.035-003, Brazil

    Lisiane Bizarro

Authors
  1. Tayfun Uzbay
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  2. Lisiane Bizarro
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Corresponding author

Correspondence to Tayfun Uzbay .

Editor information

Editors and Affiliations

  1. Section of Behavioural Pharmacology, King's College London Institute of Psychiatry P049, London, United Kingdom

    Ian P. Stolerman

  2. Brown Medical School, Butler Hospital, Providence, Rhode Island, USA

    Lawrence H. Price

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© 2014 Springer-Verlag Berlin Heidelberg

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Uzbay, T., Bizarro, L. (2014). Liquid Diet for Administering Alcohol. In: Stolerman, I., Price, L. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27772-6_153-2

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  • DOI: https://doi.org/10.1007/978-3-642-27772-6_153-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27772-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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