Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Chagas’ Disease, Man

  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_566-2

Pathology

Trypanosomacruzi infection occurs in Central and South America and is transmitted by triatomid bugs (Kissing Bugs). These hematophagous Hemiptera evacuate their intestinal contents containing the infection’s metacyclic forms, while feeding, in order to ingest more blood. Metacyclic forms enter either the skin through the site of the bite, are inoculated by scratching the itching bite wound, or penetrate the mucosa of the conjunctiva or mouth. Amastigotes multiply in adjacent muscle and fat cells in the dermis, producing an inflammatory nodule, the chagoma, which is composed of parasitized cells, histiocytes, and a periphery of neutrophilic granulocytes. This chagoma may persist for several weeks. Trypanosomes are disseminated via the lymphatics, often enlarging the regional lymph nodes. Hematogenous dissemination follows and amastigotes parasitize many tissues, especially histiocytes, adipocytes, myocardial fibers, and autonomic ganglia in the gastrointestinal tract; this is...

Keywords

Trypanosoma Cruzi Right Bundle Branch Block Autonomic Ganglion Autoimmune Pathology African Trypanosome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany