Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Plasmodium falciparum: Endothelial Receptors

  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_4778-1
Plasmodium falciparum is known by the fact that infected erythrocytes become attached at endothelial cells. This occurs by the activity of several receptors of the endothelial cells:
  • CD36: most common receptor being supported by thrombospondin

  • ICAM-1 (intercellular adhesion molecule): mostly active in brain cells

  • Fractalcine: supports adhesion in brain

  • Chondroitinsulphate A: most important receptor during pregnancy being localized on syncytiotrophoblasts of the placenta

  • Immunoglobulin G: similar effects like chondroitinsulphate A


Endothelial Cell Adhesion Molecule Plasmodium Falciparum Brain Cell Intercellular Adhesion 
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Further Reading

  1. Ho M, White N (1999) Molecular mechanisms of cytoadherence in malaria. Am J Physiol 276:C1231–C1242PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany