Encyclopedia of Parasitology

Living Edition
| Editors: Heinz Mehlhorn

Plasmodium falciparum: Endothelial Receptors

  • Heinz Mehlhorn
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27769-6_4778-1
Plasmodium falciparum is known by the fact that infected erythrocytes become attached at endothelial cells. This occurs by the activity of several receptors of the endothelial cells:
  • CD36: most common receptor being supported by thrombospondin

  • ICAM-1 (intercellular adhesion molecule): mostly active in brain cells

  • Fractalcine: supports adhesion in brain

  • Chondroitinsulphate A: most important receptor during pregnancy being localized on syncytiotrophoblasts of the placenta

  • Immunoglobulin G: similar effects like chondroitinsulphate A

Keywords

Endothelial Cell Adhesion Molecule Plasmodium Falciparum Brain Cell Intercellular Adhesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further Reading

  1. Ho M, White N (1999) Molecular mechanisms of cytoadherence in malaria. Am J Physiol 276:C1231–C1242PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany